Detalles de la búsqueda
1.
Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies.
Regul Toxicol Pharmacol
; 119: 104825, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33220389
2.
Nonclinical Development of Biologics: Integrating Safety, Pharmacokinetics, and Pharmacodynamics to Create Smarter and More Flexible Nonclinical Safety Programs Optimizing Animal Use.
Int J Toxicol
; 40(3): 270-284, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33631988
3.
Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.
Regul Toxicol Pharmacol
; 94: 91-100, 2018 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29355662
4.
Translational immunotoxicology of immunomodulatory monoclonal antibodies.
Drug Discov Today Technol
; 21-22: 85-93, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27978992
5.
Nonclinical safety testing of biopharmaceuticals--Addressing current challenges of these novel and emerging therapies.
Regul Toxicol Pharmacol
; 73(1): 265-75, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26219199
6.
Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics.
Drug Discov Today
; 28(2): 103440, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36375739
7.
A whole blood in vitro cytokine release assay with aqueous monoclonal antibody presentation for the prediction of therapeutic protein induced cytokine release syndrome in humans.
Cytokine
; 60(3): 828-37, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22986013
8.
Challenges of non-clinical safety testing for biologics: A Report of the 9th BioSafe European Annual General Membership Meeting.
MAbs
; 13(1): 1938796, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34241561
9.
Dendritic cell-based immunotherapy for prostate cancer.
Clin Dev Immunol
; 2010: 517493, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-21076523
10.
Evaluation of in vitro Assays to Assess the Modulation of Dendritic Cells Functions by Therapeutic Antibodies and Aggregates.
Front Immunol
; 10: 601, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31001248
11.
Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice.
Mol Cell Endocrinol
; 280(1-2): 39-46, 2008 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-18045774
12.
Response to the letter to the editor by Susan Thorpe et al.: how predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response.
Cytokine
; 64(1): 473-5; discussion 476, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23921146
13.
Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration.
MAbs
; 10(7): 1111-1130, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30130439
14.
Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11.
Cancer Lett
; 245(1-2): 331-6, 2007 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-16504379
15.
In vitro assays supporting the safety assessment of immunomodulatory monoclonal antibodies.
Toxicol In Vitro
; 45(Pt 3): 296-308, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28263892
16.
Tissue-specificity of prostate specific antigens: comparative analysis of transcript levels in prostate and non-prostatic tissues.
Cancer Lett
; 236(2): 229-38, 2006 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-16046056
17.
Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.
Cancer Res
; 64(7): 2357-64, 2004 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15059886
18.
Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas.
Oncol Rep
; 13(1): 139-44, 2005 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-15583815
19.
Multiple tumor marker analyses (PSA, hK2, PSCA, trp-p8) in primary prostate cancers using quantitative RT-PCR.
Int J Oncol
; 23(1): 221-8, 2003 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12792797
20.
Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro.
PLoS One
; 9(1): e86322, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24466023