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1.
Pregnenolone-methyl-ether enhances CLIP170 and microtubule functions improving spine maturation and hippocampal deficits related to CDKL5 deficiency.
Hum Mol Genet
; 31(16): 2738-2750, 2022 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35348691
2.
Loss of CDKL5 Causes Synaptic GABAergic Defects That Can Be Restored with the Neuroactive Steroid Pregnenolone-Methyl-Ether.
Int J Mol Sci
; 24(1)2022 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36613509
3.
The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.
Hum Mol Genet
; 27(12): 2052-2063, 2018 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29618004
4.
The neurosteroid pregnenolone reverts microtubule derangement induced by the loss of a functional CDKL5-IQGAP1 complex.
Hum Mol Genet
; 26(18): 3520-3530, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28641386
5.
Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder?
Int J Mol Sci
; 20(17)2019 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31438497
6.
Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Cereb Cortex
; 26(6): 2517-2529, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-25979088
7.
Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5.
J Biol Chem
; 290(7): 4512-27, 2015 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25555910
8.
Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization.
J Biol Chem
; 290(6): 3223-37, 2015 Feb 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-25527496
9.
Extrasynaptic N-methyl-D-aspartate (NMDA) receptor stimulation induces cytoplasmic translocation of the CDKL5 kinase and its proteasomal degradation.
J Biol Chem
; 286(42): 36550-8, 2011 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-21832092
10.
The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.
Hum Mol Genet
; 19(16): 3114-23, 2010 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20504995
11.
A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain.
Hum Genet
; 131(2): 187-200, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21748340
12.
What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.
Neural Plast
; 2012: 728267, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22779007
13.
Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting.
J Neuroendocrinol
; 34(2): e13033, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34495563
14.
CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery.
Hum Mol Genet
; 18(23): 4590-602, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19740913
15.
Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.
EMBO Rep
; 10(12): 1327-33, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19820693
16.
MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders.
EMBO Mol Med
; 12(6): e10270, 2020 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32383329
17.
Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice.
J Psychopharmacol
; 33(7): 894-907, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31084246
18.
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder.
Neuropharmacology
; 144: 104-114, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30326240
19.
A Novel Mecp2Y120D Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett Syndrome.
Mol Neurobiol
; 56(7): 4838-4854, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30402709
20.
Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties.
Mol Cell Biol
; 23(23): 8795-808, 2003 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-14612419