Detalles de la búsqueda
1.
NecroX Improves Polyhexamethylene Guanidine-induced Lung Injury by Regulating Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress.
Am J Respir Cell Mol Biol
; 69(1): 57-72, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36930952
2.
Mitigating Age-Related Ovarian Dysfunction with the Anti-Inflammatory Agent MIT-001.
Int J Mol Sci
; 24(20)2023 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37894838
3.
MIT-001 Restores Human Placenta-Derived Mesenchymal Stem Cells by Enhancing Mitochondrial Quiescence and Cytoskeletal Organization.
Int J Mol Sci
; 22(10)2021 May 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34064719
4.
Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response.
Thorax
; 73(8): 758-768, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29622694
5.
Pharmacokinetics and safety of a single dose of the novel necrosis inhibitor LC28-0126 in healthy male subjects.
Br J Clin Pharmacol
; 83(6): 1205-1215, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28002882
6.
The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release.
J Immunol
; 194(11): 5223-32, 2015 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25911749
7.
NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC1α expression levels during hypoxia/reoxygenation injury.
Korean J Physiol Pharmacol
; 20(2): 201-11, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26937217
8.
NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFß1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts.
Korean J Physiol Pharmacol
; 20(3): 305-14, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-27162485
9.
The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation.
Liver Int
; 35(4): 1341-53, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25443620
10.
NecroX-5 suppresses sodium nitroprusside-induced cardiac cell death through inhibition of JNK and caspase-3 activation.
Cell Biol Int
; 38(6): 702-7, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24446382
11.
In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic viruses.
Virus Res
; 342: 199325, 2024 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38309472
12.
The Effect of Necrosis Inhibitor on Dextran Sulfate Sodium Induced Chronic Colitis Model in Mice.
Pharmaceutics
; 15(1)2023 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36678851
13.
The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism.
Nat Commun
; 14(1): 5728, 2023 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37714840
14.
NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats.
Toxicol Appl Pharmacol
; 263(1): 1-6, 2012 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22659508
15.
CBP-Mediated Acetylation of Importin α Mediates Calcium-Dependent Nucleocytoplasmic Transport of Selective Proteins in Drosophila Neurons.
Mol Cells
; 45(11): 855-867, 2022 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-36172977
16.
Creation of myocardial fibrosis by transplantation of fibroblasts primed with survival factors.
Am J Physiol Heart Circ Physiol
; 301(3): H1004-14, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21685267
17.
Pharmacokinetics and Tolerability of LC28-0126, a Novel Necrosis Inhibitor, After Multiple Ascending Doses: A Phase I Randomized, Double-blind, Placebo-controlled Study in Healthy Male Subjects.
Clin Ther
; 42(10): 1946-1954.e2, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32980184
18.
Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis.
Virulence
; 11(1): 1225-1239, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32835604
19.
Therapeutic Potential of a Novel Necrosis Inhibitor, 7-Amino-Indole, in Myocardial Ischemia-Reperfusion Injury.
Hypertension
; 71(6): 1143-1155, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29661840
20.
NecroX-5 prevents breast cancer metastasis by AKT inhibition via reducing intracellular calcium levels.
Int J Oncol
; 50(1): 185-192, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27922686