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1.
Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model.
PLoS Comput Biol
; 18(7): e1010254, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35867773
2.
Use of statistical and pharmacokinetic-pharmacodynamic modeling and simulation to improve decision-making: A section summary report of the trends and innovations in clinical trial statistics conference.
J Biopharm Stat
; 27(3): 554-567, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28304215
3.
Efficacy of telaprevir-based therapy in stable liver transplant patients with chronic genotype 1 hepatitis C.
Ann Hepatol
; 15(4): 512-23, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27236150
4.
Model-based clinical drug development in the past, present and future: a commentary.
Br J Clin Pharmacol
; 79(1): 108-16, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24527997
5.
Modeling population heterogeneity in viral dynamics for chronic hepatitis C infection: Insights from Phase 3 telaprevir clinical studies.
J Pharmacokinet Pharmacodyn
; 42(6): 681-98, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26289844
6.
Physiological Indirect Response Model to Omics-Powered Quantitative Systems Pharmacology Model.
J Pharm Sci
; 113(1): 11-21, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37898164
7.
A tutorial for model-based evaluation and translation of cardiovascular safety in preclinical trials.
CPT Pharmacometrics Syst Pharmacol
; 13(1): 5-22, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37950388
8.
A viral dynamic model for treatment regimens with direct-acting antivirals for chronic hepatitis C infection.
PLoS Comput Biol
; 8(1): e1002339, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22241977
9.
Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition.
bioRxiv
; 2023 Apr 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37162938
10.
Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition.
NPJ Precis Oncol
; 7(1): 55, 2023 Jun 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37291190
11.
Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model.
Cancers (Basel)
; 15(10)2023 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37345087
12.
Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.
Elife
; 122023 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38063302
13.
A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia.
Crit Care
; 16(6): R218, 2012 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23148736
14.
Population pharmacodynamic modeling of various extended-release formulations of methylphenidate in children with attention deficit hyperactivity disorder via meta-analysis.
J Pharmacokinet Pharmacodyn
; 39(2): 161-76, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22270322
15.
Population Pharmacokinetic Modeling of Inebilizumab in Subjects with Neuromyelitis Optica Spectrum Disorders, Systemic Sclerosis, or Relapsing Multiple Sclerosis.
Clin Pharmacokinet
; 61(3): 387-400, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34718986
16.
Impact of low percentage of data below the quantification limit on parameter estimates of pharmacokinetic models.
J Pharmacokinet Pharmacodyn
; 38(4): 423-32, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21626437
17.
Systems Modeling to Quantify Safety Risks in Early Drug Development: Using Bifurcation Analysis and Agent-Based Modeling as Examples.
AAPS J
; 23(4): 77, 2021 05 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34018069
18.
A Spatial Quantitative Systems Pharmacology Platform spQSP-IO for Simulations of Tumor-Immune Interactions and Effects of Checkpoint Inhibitor Immunotherapy.
Cancers (Basel)
; 13(15)2021 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34359653
19.
Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model.
Front Immunol
; 12: 617316, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33737925
20.
Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial.
Sci Transl Med
; 13(590)2021 04 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-33883272