Detalles de la búsqueda
1.
Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients.
Proc Natl Acad Sci U S A
; 119(35): e2207531119, 2022 08 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35994639
2.
Effects of the orexin receptor 2 agonist danavorexton on emergence from general anaesthesia and opioid-induced sedation, respiratory depression, and analgesia in rats and monkeys.
Br J Anaesth
; 132(3): 541-552, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38296753
3.
TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy.
J Pharmacol Exp Ther
; 385(3): 193-204, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37001988
4.
Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals.
J Sleep Res
; 32(5): e13878, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36934366
5.
Translational Development Strategies for TAK-063, a Phosphodiesterase 10A Inhibitor.
Int J Neuropsychopharmacol
; 23(8): 524-532, 2020 11 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32598478
6.
Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents.
Int J Neuropsychopharmacol
; 23(2): 96-107, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31689714
7.
De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions.
Am J Hum Genet
; 98(4): 763-71, 2016 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27058447
8.
HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.
J Pharmacol Exp Ther
; 364(3): 377-389, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29298820
9.
An Approach to Discovering Novel Muscarinic M1 Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction.
J Pharmacol Exp Ther
; 364(1): 28-37, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29025977
10.
A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea.
Mov Disord
; 33(3): 482-488, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29392776
11.
TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Disease.
J Pharmacol Exp Ther
; 360(1): 75-83, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27811172
12.
Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report.
Int J Neuropsychopharmacol
; 20(4): 285-294, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28031269
13.
A novel Na(+) -Independent alanine-serine-cysteine transporter 1 inhibitor inhibits both influx and efflux of D-Serine.
J Neurosci Res
; 94(10): 888-95, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27302861
14.
The Phosphodiesterase 10A Selective Inhibitor TAK-063 Improves Cognitive Functions Associated with Schizophrenia in Rodent Models.
J Pharmacol Exp Ther
; 356(3): 587-95, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26675680
15.
Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [11 C]T-773 in nonhuman primates.
Synapse
; 70(6): 253-63, 2016 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-26878349
16.
In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.
J Pharmacol Exp Ther
; 352(3): 471-9, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25525190
17.
Evaluation of a novel PDE10A PET radioligand, [(11) C]T-773, in nonhuman primates: brain and whole body PET and brain autoradiography.
Synapse
; 69(7): 345-55, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25892433
18.
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor.
Bioorg Med Chem
; 23(22): 7138-49, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26494583
19.
Development of a series of novel carbon-11 labeled PDE10A inhibitors.
J Labelled Comp Radiopharm
; 58(5): 202-8, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25891816
20.
The orexin receptor 2 (OX2R)-selective agonist TAK-994 increases wakefulness without affecting cerebrospinal fluid orexin levels in cynomolgus monkeys.
Pharmacol Biochem Behav
; 234: 173690, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38061670