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1.
Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Bioorg Med Chem
; 100: 117618, 2024 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38309201
2.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25459880
3.
Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.
Bioorg Med Chem
; 23(21): 7000-6, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26455654
4.
Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.
Structure
; 30(6): 793-802.e5, 2022 06 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35395178
5.
Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors.
Biochemistry
; 50(31): 6642-54, 2011 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-21711014
6.
DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry.
ACS Med Chem Lett
; 12(7): 1166-1172, 2021 Jul 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34267887
7.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31265286
8.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31013427
9.
Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Nat Commun
; 9: 16227, 2018 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30004092
10.
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
J Med Chem
; 60(4): 1247-1261, 2017 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28151659
11.
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Nat Commun
; 8: 16081, 2017 07 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-28714473
12.
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
J Med Chem
; 59(5): 2163-78, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26854747
13.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27109867
14.
An Efficient Asymmetric Approach to Carbocyclic Nucleosides: Asymmetric Synthesis of 1592U89, a Potent Inhibitor of HIV Reverse Transcriptase.
J Org Chem
; 61(13): 4192-4193, 1996 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-11667311
15.
Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors.
Bioorg Med Chem Lett
; 17(16): 4678-82, 2007 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17576061
16.
Conversion of potent MMP inhibitors into selective TACE inhibitors.
Bioorg Med Chem Lett
; 16(4): 1028-31, 2006 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16289878
17.
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
Bioorg Med Chem Lett
; 16(10): 2699-704, 2006 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16516466
18.
Regioselectivity in the palladium-catalyzed addition of carbon nucleophiles to carbocyclic derivatives.
J Org Chem
; 67(2): 327-35, 2002 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-11798302
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