Detalles de la búsqueda
1.
Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels.
Arterioscler Thromb Vasc Biol
; 42(1): e27-e43, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34670408
2.
Gene-based therapeutics for rare genetic neurodevelopmental psychiatric disorders.
Mol Ther
; 30(7): 2416-2428, 2022 07 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35585789
3.
Current Perspectives in Autism Spectrum Disorder: From Genes to Therapy.
J Neurosci
; 36(45): 11402-11410, 2016 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27911742
4.
Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.
Biol Reprod
; 94(5): 110, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27009040
5.
Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports.
Am J Med Genet A
; 170A(5): 1165-73, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26887912
6.
Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder.
Neurobiol Dis
; 77: 220-7, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25796564
7.
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Proc Natl Acad Sci U S A
; 109(8): 3125-30, 2012 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22315408
8.
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
J Pharmacol Exp Ther
; 341(2): 396-409, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22328573
9.
Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.
Biomarkers
; 17(6): 524-31, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22672085
10.
16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons.
Front Psychiatry
; 13: 924956, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36405918
11.
Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease.
J Pharmacol Exp Ther
; 336(1): 64-76, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20923867
12.
Human inducible pluripotent stem cells: Realization of initial promise in drug discovery.
Cell Stem Cell
; 28(9): 1507-1515, 2021 09 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34478628
13.
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Cell Rep
; 31(12): 107780, 2020 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32579942
14.
Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species.
J Histochem Cytochem
; 57(10): 933-49, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19506089
15.
How to develop therapeutic and translational research collaborations with industry.
Mol Biol Cell
; 30(22): 2741-2743, 2019 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31609671
16.
Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder.
Transl Psychiatry
; 9(1): 151, 2019 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31123247
17.
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
Cell Rep
; 28(12): 3224-3237.e5, 2019 Sep 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31533043
18.
Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons.
Neuron
; 100(4): 783-797, 2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30465765
19.
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
J Med Chem
; 61(3): 1001-1018, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29293004
20.
De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome.
Mol Genet Metab Rep
; 16: 23-29, 2018 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-29922587