Detalles de la búsqueda
1.
TAAR1 agonist ulotaront delays gastric emptying of solids in patients with schizophrenia and concurrent metabolic syndrome with prediabetes.
Diabetes Obes Metab
; 26(6): 2466-2475, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38533552
2.
A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia.
N Engl J Med
; 382(16): 1497-1506, 2020 04 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32294346
3.
In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT1A Receptor Agonist for the Treatment of Schizophrenia.
Pharm Res
; 39(5): 837-850, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35484370
4.
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action.
J Pharmacol Exp Ther
; 371(1): 1-14, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31371483
5.
Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.
CNS Spectr
; 21(5): 379-384, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26780922
6.
A Novel Method for Deriving Adverse Event Prevalence in Randomized Controlled Trials: Potential for Improved Understanding of Benefit-Risk Ratio and Application to Drug Labels.
Adv Ther
; 41(1): 152-169, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37855974
7.
Estimating heterogeneity of treatment effect in psychiatric clinical trials.
medRxiv
; 2024 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38712180
8.
TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner.
Neuropsychopharmacology
; 49(7): 1091-1103, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38110609
9.
TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding.
Mol Metab
; 80: 101883, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38237896
10.
Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.
Clin Pharmacol Ther
; 2024 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-38822554
11.
Challenges in the clinical development of non-D2 compounds for schizophrenia.
Curr Med Res Opin
; 39(3): 467-471, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36416096
12.
A multicenter, double-blind, placebo-controlled, randomized, Phase 1b crossover trial comparing two doses of ulotaront with placebo in the treatment of narcolepsy-cataplexy.
Sleep Med
; 107: 202-211, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37209427
13.
Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans.
Neurol Ther
; 12(3): 815-832, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-36932300
14.
Ulotaront, a Trace Amine-Associated Receptor 1/Serotonin 5-HT1A Agonist, in Patients With Parkinson Disease Psychosis: A Pilot Study.
Neurol Clin Pract
; 13(4): e200175, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37273942
15.
Treatment with the novel TAAR1 agonist ulotaront is associated with reductions in quantitative polysomnographic REM sleep without atonia in healthy human subjects: Results of a post-hoc analysis.
Sleep Med
; 101: 578-586, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36584503
16.
Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy.
Schizophrenia (Heidelb)
; 9(1): 49, 2023 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37550314
17.
Depicting Risperidone Safety Profiles in Clinical Trials Across Different Diagnoses Using a Dopamine D2-Based Pharmacological Class Effect Query Defined by FAERS.
Clin Drug Investig
; 42(12): 1113-1121, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36350559
18.
A Randomized, Double-blind, Placebo-controlled Proof-of-Concept Trial to Evaluate the Efficacy and Safety of Non-racemic Amisulpride (SEP-4199) for the Treatment of Bipolar I Depression.
J Affect Disord
; 296: 549-558, 2022 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34614447
19.
A sensitive LC-MS/MS method for simultaneous quantification of ulotaront and its N-desmethyl metabolite in human plasma and application to a clinical study.
J Pharm Biomed Anal
; 207: 114404, 2022 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34700199
20.
Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats.
Drug Alcohol Depend
; 231: 109261, 2022 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35033729