Detalles de la búsqueda
1.
Safety, pharmacodynamics, and exposure-response modeling results from a first-in-human phase 1 study of nedosiran (PHYOX1) in primary hyperoxaluria.
Kidney Int
; 101(3): 626-634, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34481803
2.
Safety, tolerability, pharmacokinetics and pharmacodynamics of the anti-CD38 cytolytic antibody TAK-079 in healthy subjects.
Br J Clin Pharmacol
; 86(7): 1314-1325, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32045493
3.
Evaluation of the safety profile of an electronic vapour product used for two years by smokers in a real-life setting.
Regul Toxicol Pharmacol
; 92: 226-238, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29248487
4.
GP2015, a proposed etanercept biosimilar: Pharmacokinetic similarity to its reference product and comparison of its autoinjector device with prefilled syringes.
Br J Clin Pharmacol
; 83(4): 732-741, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27790726
5.
First-in-human studies of seletalisib, an orally bioavailable small-molecule PI3Kδ inhibitor for the treatment of immune and inflammatory diseases.
Eur J Clin Pharmacol
; 73(5): 581-591, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-28160012
6.
A Phase 1 randomized study on the safety and pharmacokinetics of OCS-05, a neuroprotective disease modifying treatment for Acute Optic Neuritis and Multiple Sclerosis.
Sci Rep
; 13(1): 5099, 2023 03 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36991169
7.
The effects of the dopamine D3 receptor antagonist GSK598809 on attentional bias to palatable food cues in overweight and obese subjects.
Int J Neuropsychopharmacol
; 15(2): 149-61, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21745436
8.
Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach.
Br J Clin Pharmacol
; 74(2): 376-80, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22295949
9.
Effect of dopamine D3 receptor antagonism on approach responses to food cues in overweight and obese individuals.
Behav Pharmacol
; 23(5-6): 603-8, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22772335
10.
The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface.
J Thromb Thrombolysis
; 33(1): 6-15, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22120925
11.
The relationship between fat mass, eating behaviour and obesity-related psychological traits in overweight and obese individuals.
Appetite
; 59(3): 656-61, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22898608
12.
Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters.
Appetite
; 59(1): 27-33, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22445776
13.
Use of Entero-Test, a simple approach for non-invasive clinical evaluation of the biliary disposition of drugs.
Br J Clin Pharmacol
; 72(1): 133-42, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21366667
14.
Impact of the Selective Orexin-1 Receptor Antagonist ACT-539313 on the Pharmacokinetics of the CYP3A Probe Drug Midazolam in Healthy Male Subjects.
J Clin Pharmacol
; 60(7): 931-941, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32035014
15.
The Association for Human Pharmacology in the Pharmaceutical Industry London Meeting October 2019: Impending Change, Innovation, and Future Challenges.
Front Pharmacol
; 11: 580560, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33364955
16.
The Association for Human Pharmacology in the Pharmaceutical Industry London Meeting 2018: Brexit and Other Challenges in Early Phase Drug Development.
Front Pharmacol
; 9: 1301, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30510508
17.
Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and alprazolam following insulin-induced hypoglycemia in humans.
Psychopharmacology (Berl)
; 231(19): 3817-28, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24770625
18.
Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people.
Biol Psychiatry
; 73(9): 887-94, 2013 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23245760
19.
Multiple-dose safety, pharmacokinetics, and pharmacodynamics of the µ-opioid receptor inverse agonist GSK1521498.
J Clin Pharmacol
; 52(10): 1456-67, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22162534
20.
Effects of mu opioid receptor antagonism on cognition in obese binge-eating individuals.
Psychopharmacology (Berl)
; 224(4): 501-9, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22752384