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1.
Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations.
Bioorg Chem
; 128: 106087, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35970069
2.
Dynamic Profiling and Binding Affinity Prediction of NBTI Antibacterials against DNA Gyrase Enzyme by Multidimensional Machine Learning and Molecular Dynamics Simulations.
ACS Omega
; 9(16): 18278-18295, 2024 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38680300
3.
The overview of development of novel bacterial topoisomerase inhibitors effective against multidrug-resistant bacteria in an academic environment: From early hits to in vivo active antibacterials.
Eur J Pharm Sci
; 192: 106632, 2024 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37949194
4.
Exploring Alternative Pathways to Target Bacterial Type II Topoisomerases Using NBTI Antibacterials: Beyond Halogen-Bonding Interactions.
Antibiotics (Basel)
; 12(5)2023 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37237833
5.
Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy.
Eur J Med Chem
; 250: 115160, 2023 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36753879
6.
The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV.
J Med Chem
; 65(9): 6431-6440, 2022 05 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35503563
7.
Structurally Optimized Potent Dual-Targeting NBTI Antibacterials with an Enhanced Bifurcated Halogen-Bonding Propensity.
ACS Med Chem Lett
; 12(9): 1478-1485, 2021 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34527181
8.
A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs.
Antibiotics (Basel)
; 10(7)2021 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34356782
9.
A Potent Mimetic of the Siglec-8 Ligand 6'-Sulfo-Sialyl Lewisx.
ChemMedChem
; 15(18): 1706-1719, 2020 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32744401
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