Detalles de la búsqueda
1.
Renoprotective Effect of TP0472993, a Novel and Selective 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, in Mouse Models of Renal Fibrosis.
J Pharmacol Exp Ther
; 386(1): 56-69, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37142440
2.
Synthesis and Structure-Activity Relationship of C-Phenyl D-Glucitol (TP0454614) Derivatives as Selective Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitors.
Chem Pharm Bull (Tokyo)
; 68(7): 635-652, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32611999
3.
TP0463518, a Novel Prolyl Hydroxylase Inhibitor, Specifically Induces Erythropoietin Production in the Liver.
J Pharmacol Exp Ther
; 371(3): 675-683, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31585986
4.
Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia.
Bioorg Med Chem Lett
; 28(10): 1725-1730, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29681433
5.
Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition.
J Med Chem
; 65(21): 14599-14613, 2022 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36318660
6.
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Bioorg Med Chem
; 19(5): 1580-93, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21324704
7.
Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors.
Bioorg Med Chem Lett
; 20(13): 3965-8, 2010 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20537533
8.
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
Bioorg Med Chem Lett
; 19(23): 6645-8, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19853443
9.
SGL5213, a novel and potent intestinal SGLT1 inhibitor, suppresses intestinal glucose absorption and enhances plasma GLP-1 and GLP-2 secretion in rats.
Eur J Pharmacol
; 853: 136-144, 2019 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30878385
10.
TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation.
Eur J Pharmacol
; 838: 138-144, 2018 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30179610
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