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1.
Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.
J Med Chem
; 35(8): 1451-7, 1992 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-1573639
2.
Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.
J Med Chem
; 36(8): 1090-9, 1993 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-8478906
3.
Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-one.
J Med Chem
; 35(9): 1605-9, 1992 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-1578487
4.
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-carboxylic acid (CI-996).
J Med Chem
; 36(16): 2253-65, 1993 Aug 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-8360871
5.
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.
J Med Chem
; 34(2): 518-25, 1991 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-1847426
6.
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.
J Med Chem
; 37(2): 322-8, 1994 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-8295221
7.
Pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase (PNP) inhibitors as potential T-cell selective immunosuppressive agents.
Adv Exp Med Biol
; 309A: 45-8, 1991.
Artículo
en Inglés
| MEDLINE | ID: mdl-1789265
8.
Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor.
Adv Exp Med Biol
; 309A: 41-4, 1991.
Artículo
en Inglés
| MEDLINE | ID: mdl-1789255
9.
Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
J Med Chem
; 33(8): 2070-2, 1990 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-2115586
10.
Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972.
Biochem Biophys Res Commun
; 178(3): 1351-8, 1991 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-1908235
11.
8-Amino-9-substituted guanines: potent purine nucleoside phosphorylase (PNP) inhibitors.
Agents Actions
; 21(3-4): 253-6, 1987 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-3120506
12.
The in vivo antiinflammatory effects of (E)-2,6-bis(1,1-dimethyl-ethyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethenyl ] phenol (PD 127443) a novel dual inhibitor of 5-lipoxygenase and cyclooxygenase.
Agents Actions
; 27(3-4): 391-4, 1989 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-2552768
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