Detalles de la búsqueda
1.
Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Bioorg Med Chem
; 74: 117034, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36272185
2.
Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon.
Bioorg Med Chem
; 73: 117035, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36208543
3.
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.
Nature
; 508(7496): 402-5, 2014 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-24590073
4.
BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model.
Antimicrob Agents Chemother
; 58(11): 6607-14, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25155605
5.
Synthesis and biological evaluation of Ribo 7-N/O/S pyrimidine 9-deaza C-nucleoside analogs as new antiviral agents for inhibiting HCV RNA-dependent RNA polymerases.
Eur J Med Chem
; 264: 115991, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38118393
6.
Synthesis of novel azasugar-containing 2'ß-C-Me 9-deaza nucleosides as potential anti-hepatitis C virus agents.
Nucleosides Nucleotides Nucleic Acids
; 42(4): 317-327, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36354089
7.
Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE).
J Med Chem
; 64(17): 12453-12468, 2021 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34436898
8.
Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
Bioorg Med Chem
; 17(11): 3934-58, 2009 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19409795
9.
The antithrombotic and anti-inflammatory effects of BCX-3607, a small molecule tissue factor/factor VIIa inhibitor.
Thromb Res
; 117(3): 343-9, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16378835
10.
An efficient synthesis of acyclic N7- and N9-adenine nucleosides via alkylation with secondary carbon electrophiles to introduce versatile functional groups at the C-1 position of acyclic moiety.
Nucleosides Nucleotides Nucleic Acids
; 25(2): 121-40, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16541957
11.
BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
J Infect Public Health
; 9(3): 220-6, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27095300
12.
Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents.
Nucleosides Nucleotides Nucleic Acids
; 24(10-12): 1543-68, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16438034
13.
Synthesis of 9-[1-(substituted)-2-(phosphonomethoxy)ethyl]adenine derivatives as possible antiviral agents.
Nucleosides Nucleotides Nucleic Acids
; 24(10-12): 1569-85, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16438035
14.
Synthesis of 9-[1-(1 -hydroxyethyl)-3-(phosphonomethoxy)propyl]adenine and prodrug as possible antiviral agents.
Nucleosides Nucleotides Nucleic Acids
; 24(10-12): 1587-95, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16438036
15.
Synthesis of N6-substituted 9-[3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents.
Nucleosides Nucleotides Nucleic Acids
; 24(10-12): 1597-611, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16438037
16.
Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives.
J Med Chem
; 47(8): 1919-29, 2004 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-15055992
17.
Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies.
Int Immunopharmacol
; 10(7): 784-90, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20399911
18.
Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa.
Acta Crystallogr D Biol Crystallogr
; 63(Pt 6): 689-97, 2007 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17505107
19.
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.
Bioorg Med Chem
; 15(5): 2106-19, 2007 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17218104
20.
Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase.
Bioorg Med Chem
; 13(7): 2665-78, 2005 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15755666