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1.
Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
Bioorg Med Chem
; 27(4): 579-588, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30626555
2.
Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress.
J Pharmacol Exp Ther
; 363(1): 114-125, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28790194
3.
The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.
J Pharmacol Exp Ther
; 330(3): 922-31, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19498103
4.
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J Med Chem
; 59(8): 3991-4006, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27031670
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