Detalles de la búsqueda
1.
Effect of a new squalene synthase inhibitor on an ApoE-/- mouse model of atherosclerosis.
Bioorg Med Chem
; 90: 117378, 2023 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37336084
2.
A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.
Molecules
; 27(19)2022 Sep 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-36234710
3.
Design of Multifaceted Antioxidants: Shifting towards Anti-Inflammatory and Antihyperlipidemic Activity.
Molecules
; 26(16)2021 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34443516
4.
Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules.
Med Res Rev
; 40(2): 709-752, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31512284
5.
New applications of squalene synthase inhibitors: Membrane cholesterol as a therapeutic target.
Arch Pharm (Weinheim)
; 353(9): e2000085, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-32557793
6.
Antihyperlipidemic morpholine derivatives with antioxidant activity: An investigation of the aromatic substitution.
Bioorg Med Chem
; 23(21): 7015-23, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26433631
7.
Evaluation of two novel antioxidants with differential effects on curcumin-induced apoptosis in C2 skeletal myoblasts; involvement of JNKs.
Bioorg Med Chem
; 23(3): 390-400, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25577709
8.
Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties.
Med Chem Res
; 24(4): 1725-1732, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25750501
9.
Design of Improved Antidiabetic Drugs: A Journey from Single to Multitarget Agents.
ChemMedChem
; 17(23): e202200320, 2022 12 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36184571
10.
Contribution of Deep Learning in the Investigation of Possible Dual LOX-3 Inhibitors/DPPH Scavengers: The Case of Recently Synthesized Compounds.
Bioengineering (Basel)
; 9(12)2022 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36551006
11.
Influence of Omega-3 Fatty Acid-Rich Fish Oils on Hyperlipidemia: Effect of Eel, Sardine, Trout, and Cod Oils on Hyperlipidemic Mice.
J Med Food
; 24(7): 749-755, 2021 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-33370175
12.
Design of more potent squalene synthase inhibitors with multiple activities.
Bioorg Med Chem
; 18(21): 7402-12, 2010 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20888243
13.
Antioxidant activity of newly synthesized 2,7-diazaphenothiazines.
Arch Pharm (Weinheim)
; 343(5): 268-73, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20232371
14.
Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies.
ChemMedChem
; 15(5): 392-403, 2020 03 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32017384
15.
Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives.
ACS Med Chem Lett
; 10(1): 98-104, 2019 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30655954
16.
Antiatherosclerotic properties of EP2302, a novel squalene synthase inhibitor, in the cholesterol-fed rabbit.
J Cardiovasc Pharmacol
; 51(6): 573-80, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18520953
17.
EP2306 [2-(4-biphenyl)-4-methyl-octahydro-1,4-benzoxazin-2-ol, hydrobromide], a novel squalene synthase inhibitor, reduces atherosclerosis in the cholesterol-fed rabbit.
J Pharmacol Exp Ther
; 323(3): 794-804, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17804677
18.
EP2306 and EP2302, two novel squalene synthase inhibitors, stimulate endothelial nitric oxide synthase expression in cultured endothelial cells.
Endothelium
; 14(4-5): 239-43, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17922341
19.
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
Eur J Med Chem
; 138: 748-760, 2017 Sep 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-28728107
20.
Balancing Antioxidant, Hypolipidemic and Anti-inflammatory Activity in a Single Agent: The Example of 2-Hydroxy-2-Substituted Morpholine, 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives as a Rational Therapeutic Approach against Atherosclerosis.
Curr Med Chem
; 24(12): 1214-1227, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27528055