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1.
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads.
Bioorg Med Chem Lett
; 96: 129489, 2023 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37770002
2.
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.
Molecules
; 26(19)2021 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34641337
3.
Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation.
Bioorg Med Chem Lett
; 29(18): 2565-2570, 2019 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31416666
4.
Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation.
Eur J Med Chem
; 255: 115385, 2023 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37150084
5.
Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands.
ChemMedChem
; 17(9): e202200058, 2022 05 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35170223
6.
Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities.
ACS Med Chem Lett
; 11(10): 1965-1972, 2020 Oct 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33062180
7.
Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies.
J Med Chem
; 63(9): 4867-4879, 2020 05 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32348139
8.
Asymmetric Diels-Alder reaction of 3-(acyloxy) acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors.
RSC Adv
; 9(71): 41755-41763, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-32655859
9.
Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies.
ChemMedChem
; 14(21): 1863-1872, 2019 11 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31549492
10.
Highly Selective and Potent Human ß-Secretaseâ 2 (BACE2) Inhibitors against Typeâ 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies.
ChemMedChem
; 14(5): 545-560, 2019 03 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30637955
11.
Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity.
Org Lett
; 20(22): 7293-7297, 2018 11 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30394756
12.
Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.
Eur J Med Chem
; 160: 171-182, 2018 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30340140
13.
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.
J Med Chem
; 61(10): 4561-4577, 2018 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29763303
14.
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.
ChemMedChem
; 13(8): 803-815, 2018 04 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29437300
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