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1.
Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis.
Proc Natl Acad Sci U S A
; 120(1): e2208541120, 2023 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36574661
2.
Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic ß-Cells.
Int J Mol Sci
; 24(21)2023 Nov 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37958977
3.
CARD9 Mediates Pancreatic Islet Beta-Cell Dysfunction Under the Duress of Hyperglycemic Stress.
Cell Physiol Biochem
; 56(2): 120-137, 2022 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35362297
4.
Hyperglycemic Conditions Promote Rac1-Mediated Serine536 Phosphorylation of p65 Subunit of NFκB (RelA) in Pancreatic Beta Cells.
Cell Physiol Biochem
; 56(4): 367-381, 2022 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35981264
5.
RhoG-Rac1 Signaling Pathway Mediates Metabolic Dysfunction of the Pancreatic Beta-Cells Under Chronic Hyperglycemic Conditions.
Cell Physiol Biochem
; 55(2): 180-192, 2021 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33851799
6.
P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic ß-Cells.
Cell Physiol Biochem
; 54(6): 1218-1230, 2020 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33347743
7.
CD36 mediates lipid accumulation in pancreatic beta cells under the duress of glucolipotoxic conditions: Novel roles of lysine deacetylases.
Biochem Biophys Res Commun
; 495(3): 2221-2226, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29274335
8.
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic ß-cells.
Apoptosis
; 22(5): 597-607, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28220272
9.
Glucotoxicity promotes aberrant activation and mislocalization of Ras-related C3 botulinum toxin substrate 1 [Rac1] and metabolic dysfunction in pancreatic islet ß-cells: reversal of such metabolic defects by metformin.
Apoptosis
; 22(11): 1380-1393, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28828705
10.
Role of G-proteins in islet function in health and diabetes.
Diabetes Obes Metab
; 19 Suppl 1: 63-75, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28880478
11.
A lack of 'glue' misplaces Rab27A to cause islet dysfunction in diabetes.
J Pathol
; 238(3): 375-7, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26575346
12.
NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model.
Cell Physiol Biochem
; 39(2): 760-7, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27467102
13.
Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic ß-Cells.
Cell Physiol Biochem
; 39(6): 2110-2120, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27802439
14.
VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.
Diabetologia
; 58(11): 2573-81, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26224100
15.
Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation.
Cell Physiol Biochem
; 36(1): 208-20, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25967961
16.
TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.
Diabetologia
; 57(5): 1047-56, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24554007
17.
Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells.
Apoptosis
; 19(12): 1691-701, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25292013
18.
Hyperglycemic Stress Induces Expression, Degradation, and Nuclear Association of Rho GDP Dissociation Inhibitor 2 (RhoGDIß) in Pancreatic ß-Cells.
Cells
; 13(3)2024 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38334664
19.
Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic ß-cells.
Mol Cell Endocrinol
; 580: 112104, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38013223
20.
Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic ß-cells.
Apoptosis
; 18(1): 1-8, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23054080