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1.
Probing α4ßδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4ß1δ/α4ß3δ receptor agonist on tonic and phasic inhibition in rat brain.
J Neurosci
; 34(49): 16256-72, 2014 Dec 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25471566
2.
Pregnenolone sulfate analogues differentially modulate GABAA receptor closed/desensitised states.
Br J Pharmacol
; 180(19): 2482-2499, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37194503
3.
Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain.
J Med Chem
; 65(9): 6656-6676, 2022 05 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35500061
4.
Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain.
J Med Chem
; 65(22): 15066-15084, 2022 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36346645
5.
Sex-specific alterations in GABA receptor-mediated responses in laterodorsal tegmentum are associated with prenatal exposure to nicotine.
Dev Neurobiol
; 80(5-6): 178-199, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32628361
6.
Silencing of spontaneous activity at α4ß1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology.
Br J Pharmacol
; 177(17): 3975-3990, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32484592
7.
Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors.
ACS Chem Neurosci
; 10(11): 4669-4684, 2019 11 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31589403
8.
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters.
J Med Chem
; 62(12): 5797-5809, 2019 06 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31117514
9.
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.
J Med Chem
; 62(5): 2798-2813, 2019 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30763084
10.
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site.
Eur J Med Chem
; 158: 311-321, 2018 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30223119
11.
Imidazole-4-acetic acid, a new lead structure for interaction with the taurine transporter in outer blood-retinal barrier cells.
Eur J Pharm Sci
; 103: 77-84, 2017 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-28259832
12.
Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs.
J Med Chem
; 60(21): 9022-9039, 2017 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29028338
13.
Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Typeâ A Receptor Antagonists with Effect on Retinal Vascular Tone.
ChemMedChem
; 11(20): 2299-2310, 2016 10 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27620323
14.
GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology.
Adv Pharmacol
; 72: 201-27, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25600372
15.
5-(Piperidin-4-yl)-3-hydroxypyrazole: A novel scaffold for probing the orthosteric γ-aminobutyric acid type A receptor binding site.
ChemMedChem
; 9(11): 2475-85, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25156407
16.
Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation.
J Med Chem
; 56(16): 6536-40, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23855889
17.
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.
J Med Chem
; 56(3): 1211-27, 2013 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23301527
18.
Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships.
J Med Chem
; 53(8): 3417-21, 2010 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-20355712
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