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1.
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders.
Altern Lab Anim
; 52(2): 117-131, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38235727
2.
Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans.
Environ Sci Technol
; 57(30): 10974-10984, 2023 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37478462
3.
Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation.
Environ Sci Technol
; 57(49): 20521-20531, 2023 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38008925
4.
The role of receptor-mediated activities of 4- and 5-ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in developmental toxicity.
J Appl Toxicol
; 43(6): 845-861, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36585251
5.
Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing.
Molecules
; 28(2)2023 Jan 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36677681
6.
Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.
Arch Toxicol
; 96(12): 3407-3419, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36063173
7.
Applicability of generic PBK modelling in chemical hazard assessment: A case study with IndusChemFate.
Regul Toxicol Pharmacol
; 136: 105267, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36367522
8.
Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics.
Arch Toxicol
; 94(12): 4055-4065, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33037899
9.
Time-Resolved Freely Dissolved Concentrations of Semivolatile and Hydrophobic Test Chemicals in In Vitro Assays-Measuring High Losses and Crossover by Headspace Solid-Phase Microextraction.
Chem Res Toxicol
; 32(9): 1780-1790, 2019 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-31426631
10.
Influence of in Vitro Assay Setup on the Apparent Cytotoxic Potency of Benzalkonium Chlorides.
Chem Res Toxicol
; 32(6): 1103-1114, 2019 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31012305
11.
Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs.
Arch Toxicol
; 93(8): 2115-2125, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31256212
12.
A novel hypothesis for an alkaline phosphatase 'rescue' mechanism in the hepatic acute phase immune response.
Biochim Biophys Acta
; 1832(12): 2044-56, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23899605
13.
Use of Physiologically Based Kinetic Modeling to Predict Deoxynivalenol Metabolism and Its Role in Intestinal Inflammation and Bile Acid Kinetics in Humans.
J Agric Food Chem
; 72(1): 761-772, 2024 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-38131302
14.
The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models.
Toxicology
; 485: 153411, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36572169
15.
Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone.
Front Pharmacol
; 14: 1248882, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37745076
16.
Quantifying processes determining the free concentration of phenanthrene in Basal cytotoxicity assays.
Chem Res Toxicol
; 25(2): 436-45, 2012 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22242923
17.
Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis.
Environ Sci Technol
; 46(17): 9690-700, 2012 Sep 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-22835061
18.
Dynamic Mass Balance Modeling for Chemical Distribution Over Time in In Vitro Systems With Repeated Dosing.
Front Toxicol
; 4: 911128, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36071822
19.
Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study.
Front Toxicol
; 4: 864441, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35516525
20.
A regression-based QSAR-model to predict acute toxicity of aromatic chemicals in tadpoles of the Japanese brown frog (Rana japonica): Calibration, validation, and future developments to support risk assessment of chemicals in amphibians.
Sci Total Environ
; 830: 154795, 2022 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35341855