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1.
Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis.
Haemophilia
; 26(1): 164-172, 2020 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-31797491
2.
Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches.
J Pharmacokinet Pharmacodyn
; 44(4): 325-333, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28389762
3.
Population Pharmacokinetic Modelling of Morphine, Gabapentin and their Combination in the Rat.
Pharm Res
; 33(11): 2630-43, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27380190
4.
Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model.
Pharm Res
; 33(5): 1133-43, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26780452
5.
A Pharmacokinetic-Pharmacodynamic Model of Morphine Exposure and Subsequent Morphine Consumption in Postoperative Pain.
Pharm Res
; 33(5): 1093-103, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26753622
6.
Moxifloxacin pharmacokinetic profile and efficacy evaluation in empiric treatment of community-acquired pneumonia.
Antimicrob Agents Chemother
; 59(4): 2398-404, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25666151
7.
Population pharmacokinetics of piperacillin in the early phase of septic shock: does standard dosing result in therapeutic plasma concentrations?
Antimicrob Agents Chemother
; 59(11): 7018-26, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26349823
8.
Repeated Time-to-event Analysis of Consecutive Analgesic Events in Postoperative Pain.
Anesthesiology
; 123(6): 1411-9, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26495978
9.
In vivo and in vitro evaluations of intestinal gabapentin absorption: effect of dose and inhibitors on carrier-mediated transport.
Pharm Res
; 32(3): 898-909, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25182974
10.
Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.
Bioorg Med Chem Lett
; 25(6): 1212-6, 2015 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25701253
11.
Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
Int J Neuropsychopharmacol
; 13(8): 1021-33, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20569520
12.
High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design.
PLoS One
; 15(11): e0242169, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33180816
13.
Pharmacokinetics of sertindole and its metabolite dehydrosertindole in rats and characterization of their comparative pharmacodynamics based on in vivo D2 receptor occupancy and behavioural conditioned avoidance response.
Biopharm Drug Dispos
; 30(4): 209-20, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19475539
14.
Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats.
J Thromb Haemost
; 17(6): 964-974, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30924607
15.
Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics.
Eur J Pharmacol
; 584(2-3): 318-27, 2008 Apr 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18325493
16.
Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors.
Eur J Pharm Sci
; 123: 531-538, 2018 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30077714
17.
Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia.
Eur J Pharm Sci
; 115: 196-203, 2018 Mar 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-29369801
18.
Quantification of the Pharmacodynamic Interaction of Morphine and Gabapentin Using a Response Surface Approach.
AAPS J
; 19(6): 1804-1813, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28853055
19.
Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis.
Basic Clin Pharmacol Toxicol
; 120(1): 71-78, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27430990
20.
Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment.
Eur J Pharmacol
; 542(1-3): 108-15, 2006 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16806167