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1.
Influence of process conditions on the crystallization and transition of metastable mannitol forms in protein formulations during lyophilization.
Pharm Res
; 30(1): 131-9, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22907420
2.
Effect of pH and excipients on structure, dynamics, and long-term stability of a model IgG1 monoclonal antibody upon freeze-drying.
Pharm Res
; 30(4): 968-84, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23184227
3.
Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation.
Pharm Res
; 29(1): 209-24, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21845507
4.
Multistep aggregation pathway of human interleukin-1 receptor antagonist: kinetic, structural, and morphological characterization.
Biophys J
; 96(1): 199-208, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19134476
5.
Differentiation and quantitative determination of surface and hydrate water in lyophilized mannitol using NIR spectroscopy.
J Pharm Sci
; 95(9): 2077-86, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16850397
6.
Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor.
J Pharm Sci
; 95(7): 1480-97, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16729274
7.
Active dimer of Epratuzumab provides insight into the complex nature of an antibody aggregate.
J Pharm Sci
; 95(1): 126-45, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16315222
8.
Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor.
Protein Sci
; 12(5): 903-13, 2003 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12717013
9.
Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution.
J Pharm Sci
; 93(12): 3076-89, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15514986
10.
Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures.
J Pharm Sci
; 93(3): 684-96, 2004 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-14762907
11.
IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers.
J Pharm Sci
; 102(3): 852-65, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23280943
12.
Rational design of lyophilized high concentration protein formulations-mitigating the challenge of slow reconstitution with multidisciplinary strategies.
Eur J Pharm Biopharm
; 85(2): 287-93, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23702275
13.
Development of stable lyophilized protein drug products.
Curr Pharm Biotechnol
; 13(3): 471-96, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22283723
14.
Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution.
J Pharm Sci
; 98(9): 3167-81, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19360857
15.
Characterization of mannitol polymorphic forms in lyophilized protein formulations using a multivariate curve resolution (MCR)-based Raman spectroscopic method.
Pharm Res
; 25(10): 2292-301, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18523875
16.
Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics.
Biochemistry
; 46(21): 6213-24, 2007 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17480058
17.
Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation.
Pharm Res
; 20(9): 1325-36, 2003 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-14567625
18.
Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition.
Biochemistry
; 41(20): 6422-31, 2002 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-12009905
19.
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.
Biochemistry
; 42(3): 829-37, 2003 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-12534296
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