Detalles de la búsqueda
1.
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.
Nature
; 615(7950): 134-142, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36470304
2.
Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.
J Mol Cell Cardiol
; 167: 92-96, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35339512
3.
Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention.
J Interv Cardiol
; 2022: 9154048, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36262459
4.
Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function.
Br J Clin Pharmacol
; 88(12): 5295-5306, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35748053
5.
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.
Circulation
; 135(12): 1160-1173, 2017 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-28137936
6.
The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan.
Front Pharmacol
; 15: 1369489, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38655187
7.
Expression of the apelin receptor, a novel potential therapeutic target, and its endogenous ligands in diverse stem cell populations in human glioblastoma.
Front Neurosci
; 18: 1379658, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38803685
8.
Co-localization of the sodium-glucose co-transporter-2 channel (SGLT-2) with endothelin ETA and ETB receptors in human cardiorenal tissue.
Biosci Rep
; 44(6)2024 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38747277
9.
Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands.
Front Endocrinol (Lausanne)
; 14: 1139121, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36967803
10.
Inducible apelin receptor knockdown reduces differentiation efficiency and contractility of hESC-derived cardiomyocytes.
Cardiovasc Res
; 119(2): 587-598, 2023 03 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-36239923
11.
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA.
Peptides
; 145: 170642, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34455010
12.
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites.
Sci Rep
; 11(1): 24336, 2021 12 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34934117
13.
Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10.
Peptides
; 136: 170440, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33171278
14.
Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection.
Commun Biol
; 4(1): 926, 2021 07 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-34326460
15.
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
Front Pharmacol
; 11: 588669, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33716722
16.
Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.
Basic Clin Pharmacol Toxicol
; 126 Suppl 6: 96-103, 2020 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-30901161
17.
Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor.
Peptides
; 121: 170139, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31472173
18.
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Sci Rep
; 9(1): 19934, 2019 12 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31882594
19.
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
Br J Pharmacol
; 176(9): 1206-1221, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30710493
20.
Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function.
Peptides
; 29(5): 735-42, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-17905478