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1.
Dostarlimab, an anti-programmed death-1 monoclonal antibody, does not cause QT prolongation in patients with solid tumours: A concentration-QT analysis.
Br J Clin Pharmacol
; 89(7): 2272-2282, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36823349
2.
Exposure-response analysis of blinatumomab in patients with relapsed/refractory acute lymphoblastic leukaemia and comparison with standard of care chemotherapy.
Br J Clin Pharmacol
; 85(4): 807-817, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30645768
3.
Population pharmacokinetics and exposure-response modeling and simulation for evolocumab in healthy volunteers and patients with hypercholesterolemia.
J Pharmacokinet Pharmacodyn
; 45(3): 505-522, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29736889
4.
Assessment of pharmacokinetic interaction between rilotumumab and epirubicin, cisplatin and capecitabine (ECX) in a Phase 3 study in gastric cancer.
Br J Clin Pharmacol
; 83(5): 1048-1055, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27966237
5.
FLT3 and CDK4/6 inhibitors: signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia.
J Pharmacokinet Pharmacodyn
; 41(6): 675-91, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25326874
6.
Model-based meta-analysis of non-small cell lung cancer with standard of care PD-1 inhibitors and chemotherapy for early development decision making.
CPT Pharmacometrics Syst Pharmacol
; 12(11): 1751-1763, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-36642813
7.
Development of a Population Pharmacokinetic Model for the Diroximel Fumarate Metabolites Monomethyl Fumarate and 2-Hydroxyethyl Succinimide Following Oral Administration of Diroximel Fumarate in Healthy Participants and Patients with Multiple Sclerosis.
Neurol Ther
; 11(1): 353-371, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-35041178
8.
Phase II Dose Selection for Alpha Synuclein-Targeting Antibody Cinpanemab (BIIB054) Based on Target Protein Binding Levels in the Brain.
CPT Pharmacometrics Syst Pharmacol
; 9(9): 515-522, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32613752
9.
Population Pharmacokinetics of Blinatumomab in Pediatric and Adult Patients with Hematological Malignancies.
Clin Pharmacokinet
; 59(4): 463-474, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31679130
10.
In vitro metabolism of the novel, highly selective oral angiogenesis inhibitor motesanib diphosphate in preclinical species and in humans.
Drug Metab Dispos
; 37(7): 1378-94, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19372226
11.
Impact of Target-Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).
J Clin Pharmacol
; 57(5): 616-626, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27861991
12.
Population pharmacokinetics analysis of AMG 416, an allosteric activator of the calcium-sensing receptor, in subjects with secondary hyperparathyroidism receiving hemodialysis.
J Clin Pharmacol
; 55(6): 620-8, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25581635
13.
Differential Pharmacokinetics of Ganitumab in Patients With Metastatic Pancreatic Cancer Versus Other Advanced Solid Cancers.
Clin Pharmacol Drug Dev
; 2(4): 367-78, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27121941
14.
Exposure-response relationship of AMG 386 in combination with weekly paclitaxel in recurrent ovarian cancer and its implication for dose selection.
Cancer Chemother Pharmacol
; 69(5): 1135-44, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22210018
15.
Population pharmacokinetic/pharmacodynamic modeling for the time course of tumor shrinkage by motesanib in thyroid cancer patients.
Cancer Chemother Pharmacol
; 66(6): 1151-8, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20872145
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