Detalles de la búsqueda
1.
Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3ß Inhibitors with Improved Metabolic Stability.
Int J Mol Sci
; 21(21)2020 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33105671
2.
Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3ß Inhibitors.
Molecules
; 24(12)2019 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31242571
3.
From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors.
Molecules
; 22(10)2017 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29036906
4.
Design and Optimization of Novel Benzimidazole- and Imidazo[4,5-b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities.
J Med Chem
; 66(11): 7304-7330, 2023 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37226670
5.
Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors.
Nat Commun
; 13(1): 569, 2022 01 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35091547
6.
Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.
Eur J Med Chem
; 235: 114234, 2022 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35325634
7.
Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer.
J Med Chem
; 65(6): 4616-4632, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35286086
8.
Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells.
ACS Pharmacol Transl Sci
; 5(8): 573-602, 2022 Aug 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35983274
9.
Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation.
J Med Chem
; 65(19): 13365-13384, 2022 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36150079
10.
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
J Med Chem
; 65(4): 3173-3192, 2022 02 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35167750
11.
Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2).
Cancers (Basel)
; 13(20)2021 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34680283
12.
Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.
J Med Chem
; 64(18): 13451-13474, 2021 09 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34506142
13.
Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Eur J Med Chem
; 208: 112721, 2020 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33035818
14.
Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.
J Med Chem
; 63(13): 7347-7354, 2020 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32462866
15.
Pyridinylimidazoles as GSK3ß Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks.
ACS Med Chem Lett
; 10(10): 1407-1414, 2019 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31620226
16.
Pyridinylimidazoles as dual glycogen synthase kinase 3ß/p38α mitogen-activated protein kinase inhibitors.
Eur J Med Chem
; 175: 309-329, 2019 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31096153
17.
Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors.
J Med Chem
; 62(23): 10757-10782, 2019 12 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31702918
18.
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.
Eur J Med Chem
; 182: 111624, 2019 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31445234
19.
Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3.
ACS Omega
; 3(7): 7809-7831, 2018 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-30087925
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