Detalles de la búsqueda
1.
Considerations and recommendations for assessment of plasma protein binding and drug-drug interactions for siRNA therapeutics.
Nucleic Acids Res
; 50(11): 6020-6037, 2022 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35687098
2.
Absorption, Distribution, Metabolism, and Excretion of [14C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies.
Drug Metab Dispos
; 51(7): 873-883, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37308298
3.
MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Blood
; 133(13): 1507-1516, 2019 03 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30692123
4.
Pradigastat disposition in humans: in vivo and in vitro investigations.
Xenobiotica
; 47(12): 1077-1089, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27855567
5.
Pharmacokinetics and safety of sacubitril/valsartan (LCZ696) in patients with mild and moderate hepatic impairmentâ©.
Int J Clin Pharmacol Ther
; 55(9): 728-739, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28737127
6.
The DGAT1 inhibitor pradigastat does not induce photosensitivity in healthy human subjects: a randomized controlled trial using three defined sunlight exposure conditions.
Photochem Photobiol Sci
; 15(9): 1155-1162, 2016 08 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-27471837
7.
Bioequivalence and food effect assessment for vildagliptin/metformin fixed-dose combination tablets relative to free combination of vildagliptin and metformin in Japanese healthy subjects.
Int J Clin Pharmacol Ther
; 54(4): 305-14, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26932305
8.
Evaluation of a potential transporter-mediated drug interaction between rosuvastatin and pradigastat, a novel DGAT-1 inhibitor.
Int J Clin Pharmacol Ther
; 53(5): 345-55, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25740267
9.
Novel orally swallowable IntelliCap(®) device to quantify regional drug absorption in human GI tract using diltiazem as model drug.
AAPS PharmSciTech
; 15(6): 1490-7, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25023947
10.
Pharmacokinetics of vildagliptin in patients with varying degrees of renal impairment.
Int J Clin Pharmacol Ther
; 51(9): 693-703, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23782585
11.
Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with Type 2 diabetes.
Int J Clin Pharmacol Ther
; 51(8): 641-51, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23782587
12.
Translational Population-Pharmacodynamic Modeling of a Novel Long-Acting siRNA Therapy, Inclisiran, for the Treatment of Hypercholesterolemia.
Clin Pharmacol Ther
; 113(2): 328-338, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36281788
13.
Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
Kidney Int Rep
; 8(12): 2754-2764, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38106570
14.
Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251).
J Cyst Fibros
; 20(2): 250-256, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33293212
15.
Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial.
Int J Chron Obstruct Pulmon Dis
; 15: 2399-2409, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33116455
16.
TORC1 inhibition enhances immune function and reduces infections in the elderly.
Sci Transl Med
; 10(449)2018 07 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29997249
17.
Drug disease interactions: role of inflammatory mediators in pain and variability in analgesic drug response.
J Pharm Pharm Sci
; 10(4): 554-66, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-18261375
18.
Drug disease interactions: role of inflammatory mediators in depression and variability in antidepressant drug response.
J Pharm Pharm Sci
; 9(3): 292-306, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-17207413
19.
Population pharmacokinetic modeling and noncompartmental analysis demonstrated bioequivalence between metformin component of metformin/vildagliptin fixed-dose combination products and metformin immediate-release tablet sourced from various countries.
Clin Pharmacol Drug Dev
; 5(1): 40-51, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27119577
20.
Effect of Pradigastat, a Diacylglycerol Acyltransferase 1 Inhibitor, on the QTcF Interval in Humans.
Clin Pharmacol Drug Dev
; 5(6): 450-459, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27274009