Detalles de la búsqueda
1.
Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals.
Pharm Res
; 40(11): 2747-2758, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37833570
2.
Deuterated driven new chemical entities: An optimistic way to improve therapeutic efficacy.
Bioorg Chem
; 135: 106490, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37001472
3.
Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold.
Drug Dev Res
; 84(4): 681-702, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-36872587
4.
Structure-activity relationship studies of functionalized aromatic peptidomimetics as neurolysin activators.
Bioorg Med Chem Lett
; 64: 128669, 2022 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35292343
5.
Antiproliferative Efficacy of N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis.
Molecules
; 26(15)2021 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34361570
6.
Development of novel carbazole derivatives with effective multifunctional action against Alzheimer's diseases: Design, synthesis, in silico, in vitro and in vivo investigation.
Bioorg Chem
; 95: 103524, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31918396
7.
Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation.
Molecules
; 25(13)2020 Jul 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32635530
8.
Design, synthesis, in silico and biological evaluation of novel 2-(4-(4-substituted piperazin-1-yl)benzylidene)hydrazine carboxamides.
Mol Divers
; 21(1): 163-174, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28039637
9.
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-ß-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.
Bioorg Med Chem
; 24(16): 3829-41, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27353888
10.
Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors.
J Enzyme Inhib Med Chem
; 31(sup2): 174-179, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27314170
11.
Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4.
Biochem Biophys Res Commun
; 456(1): 312-9, 2015 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-25434996
12.
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Bioorg Med Chem Lett
; 25(5): 1092-9, 2015 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25619635
13.
Regulation of TRP channels by steroids: Implications in physiology and diseases.
Gen Comp Endocrinol
; 220: 23-32, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25449179
14.
Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells.
Cell Biol Int
; 38(10): 1118-31, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24804954
15.
Exploring Dendritic and Spine Structural Profiles in Epilepsy: Insights From Human Studies and Experimental Animal Models.
Epilepsy Curr
; 24(1): 40-46, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38327540
16.
Identification of the novel HLA-B*40:06:01:18 allele in a North Indian individual.
HLA
; 103(3): e15436, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38470352
17.
Preferential transport of synaptic vesicles across neuronal branches is regulated by the levels of the anterograde motor UNC-104/KIF1A in vivo.
Genetics
; 227(1)2024 05 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38467475
18.
Recent advances in multitarget-directed ligands via in silico drug discovery.
Drug Discov Today
; 29(3): 103904, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38280625
19.
Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer's disease: In silico, In vitro, and In vivo investigation.
Biomed Pharmacother
; 174: 116484, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38565058
20.
The impact of value-driven outcomes initiative on endo-laparoscopic groin hernia repair.
Hernia
; 27(5): 1299-1306, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36427167