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1.
Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.
Bioorg Med Chem
; 20(2): 1060-75, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22197396
2.
A novel series of (S)-2,7-substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor α/γ dual agonists with protein-tyrosine phosphatase 1B inhibitory activity.
Chem Pharm Bull (Tokyo)
; 59(10): 1233-42, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21963632
3.
Novel acyl-CoA: cholesterol acyltransferase inhibitor: indoline-based sulfamide derivatives with low lipophilicity and protein binding ratio.
Chem Pharm Bull (Tokyo)
; 58(8): 1057-65, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20686260
4.
Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation.
Chem Pharm Bull (Tokyo)
; 58(8): 1066-76, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20686261
5.
Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities.
Bioorg Med Chem
; 17(16): 6020-31, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19608421
6.
Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db/db mice--possible dysfunction of receptor and/or receptor-G protein coupling.
Naunyn Schmiedebergs Arch Pharmacol
; 377(4-6): 401-10, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18228001
7.
Regional heterogeneity of substance P-induced endothelium-dependent contraction, relaxation, and -independent contraction in rabbit pulmonary arteries.
Life Sci
; 83(23-24): 810-4, 2008 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-18952112
8.
Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells.
Life Sci
; 82(1-2): 79-84, 2008 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-18037448
9.
Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats.
Life Sci
; 79(5): 442-7, 2006 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16481007
10.
Novel prodrugs of meropenem with two lipophilic promoieties: synthesis and pharmacokinetics.
J Antibiot (Tokyo)
; 64(3): 233-42, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21224861
11.
Computational design and selections for an engineered, thermostable terpene synthase.
Protein Sci
; 20(9): 1597-606, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21739507
12.
Lipopolysaccharide-induced impairment of nitric oxide-mediated vasorelaxation and protective effects of nitric oxide synthesis inhibitors in isolated rat mesenteric arteries.
Arzneimittelforschung
; 60(6): 315-9, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20648920
13.
NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries.
Vascul Pharmacol
; 51(2-3): 147-53, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19539781
14.
Relationships between lipophilicity and biological activities in a series of indoline-based anti-oxidative acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
Arzneimittelforschung
; 58(12): 666-72, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-19202739
15.
Synthesis and biological evaluation of (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: a novel series of PPAR gamma agonists.
Chem Pharm Bull (Tokyo)
; 56(3): 335-45, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18310946
16.
Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.
J Med Chem
; 51(15): 4823-33, 2008 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-18620381
17.
Synergistic effect of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced paw edema in rats.
Arzneimittelforschung
; 56(10): 695-9, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-17225565
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