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1.
HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.
J Pharmacol Exp Ther
; 364(3): 377-389, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29298820
2.
Identification of a novel series of potent and selective CCR6 inhibitors as biological probes.
Bioorg Med Chem Lett
; 28(18): 3067-3072, 2018 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30098865
3.
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors.
Bioorg Med Chem
; 24(23): 6149-6165, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27825552
4.
Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1â³ binding site.
Bioorg Med Chem
; 22(19): 5487-505, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25192810
5.
Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
Sci Rep
; 11(1): 14532, 2021 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34267258
6.
TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology
; 44(5): 961-970, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30209408
7.
Identification of 3,4-dihydro-2H-thiochromene 1,1-dioxide derivatives with a phenoxyethylamine group as highly potent and selective α1D adrenoceptor antagonists.
Eur J Med Chem
; 139: 114-127, 2017 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28800452
8.
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
J Med Chem
; 60(2): 608-626, 2017 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27966948
9.
Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities.
J Med Chem
; 59(7): 2989-3002, 2016 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26954848
10.
Author Correction: Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
Sci Rep
; 11(1): 15255, 2021 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34290388
11.
Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach.
J Med Chem
; 57(21): 8886-902, 2014 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25264600
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