Detalles de la búsqueda
1.
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer.
J Pharmacol Exp Ther
; 352(2): 327-37, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25502803
2.
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.
Bioorg Med Chem
; 22(23): 6570-6585, 2014 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25456383
3.
Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3).
Bioorg Med Chem Lett
; 22(22): 6938-42, 2012 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23044369
4.
Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett
; 22(6): 2262-5, 2012 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22365755
5.
Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.
J Med Chem
; 51(11): 3065-8, 2008 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-18447379
6.
Discovery of amido-benzisoxazoles as potent c-Kit inhibitors.
Bioorg Med Chem Lett
; 18(18): 5115-7, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18723346
7.
Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies.
ACS Med Chem Lett
; 7(7): 719-23, 2016 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27437084
8.
Diastereoselective synthesis of the endo- and exo-spirotetronate subunits of the quartromicins. The first enantioselective Diels-Alder reaction of an acyclic (Z)-1,3-diene.
Org Lett
; 4(9): 1543-6, 2002 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-11975624
9.
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A).
J Med Chem
; 57(15): 6632-41, 2014 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25062128
10.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
J Med Chem
; 57(7): 3094-116, 2014 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24611879
11.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
J Med Chem
; 57(2): 325-38, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405213
12.
Design, optimization, and biological evaluation of novel keto-benzimidazoles as potent and selective inhibitors of phosphodiesterase 10A (PDE10A).
J Med Chem
; 56(21): 8781-92, 2013 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24102193
13.
Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer.
J Med Chem
; 55(10): 4776-87, 2012 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22548439
14.
Enantioselective organocatalytic cyclopropanations. The identification of a new class of iminium catalyst based upon directed electrostatic activation.
J Am Chem Soc
; 127(10): 3240-1, 2005 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15755116
Resultados
1 -
14
de 14
1
Próxima >
>>