Detalles de la búsqueda
1.
Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
Bioorg Med Chem
; 98: 117581, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38176113
2.
Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models.
Br J Cancer
; 126(5): 744-753, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34795410
3.
Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity.
Bioorg Med Chem
; 71: 116949, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35926326
4.
Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.
Bioorg Med Chem
; 28(5): 115307, 2020 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32007387
5.
Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity.
Chem Pharm Bull (Tokyo)
; 68(5): 452-465, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32378543
6.
Discovery of 3,5-Dimethylpyridin-4(1H)-one Derivatives as Activators of AMP-Activated Protein Kinase (AMPK).
Chem Pharm Bull (Tokyo)
; 68(1): 77-90, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-31902903
7.
A real-world, retrospective, observational study examining treatment patterns and clinical outcomes in patients with FLT3m + AML in Japan.
Curr Med Res Opin
; : 1-10, 2023 Oct 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37881860
8.
New imidazopyridopyrimidine:naphthyridine base-pairing motif, ImN(N):NaO(O), consisting of a DAAD:ADDA hydrogen bonding pattern, markedly stabilize DNA duplexes.
Chem Commun (Camb)
; 47(38): 10818-20, 2011 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21863185
9.
Synthesis of 1,8-naphthyridine C-nucleosides and their base-pairing properties in oligodeoxynucleotides: thermally stable naphthyridine:imidazopyridopyrimidine base-pairing motifs.
Angew Chem Int Ed Engl
; 44(4): 596-8, 2005 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-15612071
10.
Synthesis and characterization of oligodeoxynucleotides containing naphthyridine:imidazopyridopyrimidine base pairs at their sticky ends. Application as thermally stabilized decoy molecules.
Chembiochem
; 7(12): 1970-5, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17031887
11.
Hybridization properties and enzymatic recognitions of naphthyridine:imidazopyridopyrimidine base pairs.
Nucleic Acids Symp Ser (Oxf)
; (50): 153-4, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-17150863
12.
Properties and application of oligodeoxynucleotides containing the naphthyridine:imidazopyridopyrimidine base pairs with the ability to form four hydrogen bonds.
Nucleic Acids Symp Ser (Oxf)
; (48): 295-6, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-17150595
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