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1.
Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.
Proc Natl Acad Sci U S A
; 115(33): E7776-E7785, 2018 08 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30061420
2.
Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.
Bioorg Med Chem
; 26(9): 2452-2465, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29669694
3.
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.
Bioorg Med Chem
; 25(14): 3658-3670, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28533114
4.
Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Bioorg Med Chem
; 25(7): 2133-2147, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28284870
5.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers.
Bioorg Med Chem
; 20(12): 3925-38, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22579619
6.
A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery.
Sci Adv
; 7(21)2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34020950
7.
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
ACS Med Chem Lett
; 11(8): 1645-1652, 2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34345355
8.
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
J Med Chem
; 63(6): 3215-3226, 2020 03 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32142284
9.
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
J Med Chem
; 63(3): 1084-1104, 2020 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31895562
10.
Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.
Sci Adv
; 5(5): eaav3660, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31131319
11.
Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.
ACS Med Chem Lett
; 10(10): 1498-1503, 2019 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31620240
12.
Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors.
FEBS Open Bio
; 7(4): 495-503, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28396835
13.
Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).
J Med Chem
; 55(9): 4446-56, 2012 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22512618
14.
CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]-N,N'-diphenylureas.
Bioorg Med Chem
; 12(9): 2295-306, 2004 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15080927
15.
CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives.
Chem Pharm Bull (Tokyo)
; 52(1): 63-73, 2004 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-14709870
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