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1.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Proc Natl Acad Sci U S A
; 116(8): 3072-3081, 2019 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30718425
2.
The Relative Association of Collective Efficacy in School and Neighborhood Contexts With Adolescent Alcohol Use.
J Epidemiol
; 29(10): 384-390, 2019 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30224580
3.
Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase.
Drug Metab Dispos
; 44(1): 115-23, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26558823
4.
Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib.
Xenobiotica
; 46(11): 967-76, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26899628
5.
Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin.
Biopharm Drug Dispos
; 36(6): 352-363, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25765700
6.
Hepatic microsomal thiol methyltransferase is involved in stereoselective methylation of pharmacologically active metabolite of prasugrel.
Drug Metab Dispos
; 42(7): 1138-45, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24733788
7.
6ß-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.
Drug Metab Dispos
; 42(4): 685-94, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24487120
8.
Absorption, distribution, metabolism and excretion of loxoprofen after dermal application of loxoprofen gel to rats.
Xenobiotica
; 44(11): 1026-38, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24916900
9.
Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine.
Drug Metab Dispos
; 41(5): 1156-62, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23471504
10.
Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6ß-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects.
Pharm Res
; 30(2): 447-57, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23073666
11.
Glutaredoxin is involved in the formation of the pharmacologically active metabolite of clopidogrel from its GSH conjugate.
Drug Metab Dispos
; 40(9): 1854-9, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22733806
12.
Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: molecular identification and contribution to plasma metabolism.
Drug Metab Dispos
; 40(2): 374-80, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22086979
13.
Novel comb-shaped PEG modification enhances the osteoclastic inhibitory effect and bone delivery of osteoprotegerin after intravenous administration in ovariectomized rats.
Pharm Res
; 29(11): 3143-55, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22729371
14.
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes.
Pharmacol Res Perspect
; 10(6): e01030, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36424908
15.
Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine.
J Biol Chem
; 285(16): 11892-902, 2010 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-20177059
16.
Glutaredoxin and thioredoxin can be involved in producing the pharmacologically active metabolite of a thienopyridine antiplatelet agent, prasugrel.
Drug Metab Dispos
; 39(2): 208-14, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21036950
17.
Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats.
Drug Metab Dispos
; 39(10): 1946-53, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21712433
18.
The intestine as an important contributor to prasugrel active metabolite formation in vivo.
Drug Metab Dispos
; 39(4): 565-70, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21189331
19.
Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach.
Drug Metab Dispos
; 39(5): 820-9, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21282406
20.
Role of domains within the autotransporter Hbp/Tsh.
Acta Crystallogr D Biol Crystallogr
; 66(Pt 12): 1295-300, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21123869