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1.
Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease.
J Lipid Res
; 61(8): 1192-1202, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32482718
2.
Selective Activation of AMPK ß1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J Pharmacol Exp Ther
; 361(2): 303-311, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28289077
3.
Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
Biochem J
; 473(5): 581-92, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26635351
4.
Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators.
Bioorg Med Chem Lett
; 26(21): 5139-5148, 2016 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27727125
5.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Angew Chem Int Ed Engl
; 55(33): 9601-5, 2016 08 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27355874
6.
Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype.
Protein Expr Purif
; 110: 22-9, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25620107
7.
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem J
; 460(2): 211-22, 2014 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24593284
8.
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Bioorg Med Chem Lett
; 24(17): 4132-40, 2014 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25113930
9.
Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship.
Bioorg Med Chem
; 19(3): 1242-55, 2011 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21236687
10.
Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.
Protein Expr Purif
; 73(2): 189-97, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20451617
11.
Expression, purification and functional characterization of IkappaB kinase-2 (IKK-2) mutants.
Protein Expr Purif
; 72(2): 254-61, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20176108
12.
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life.
Bioorg Med Chem Lett
; 20(23): 7159-63, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20709553
13.
The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate.
Bioorg Med Chem Lett
; 20(23): 7155-8, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21055613
14.
Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.
Biochemistry
; 48(27): 6402-11, 2009 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-19496616
15.
Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
Bioorg Med Chem Lett
; 19(16): 4882-4, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616942
16.
Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency.
Bioorg Med Chem Lett
; 19(16): 4878-81, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616945
17.
Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions.
J Comput Aided Mol Des
; 23(1): 13-24, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18777160
18.
Structural Basis for Achieving GSK-3ß Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.
J Med Chem
; 62(21): 9600-9617, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31535859
19.
Biophysical Interactions of Direct AMPK Activators.
Methods Mol Biol
; 1732: 29-55, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29480467
20.
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(16): 7273-7288, 2018 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30036059