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1.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Proc Natl Acad Sci U S A
; 116(8): 3072-3081, 2019 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30718425
2.
CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
Mol Pharmacol
; 96(5): 600-608, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31455676
3.
Human small intestinal epithelial cells differentiated from adult intestinal stem cells as a novel system for predicting oral drug absorption in humans.
Drug Metab Dispos
; 42(11): 1947-54, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25200868
4.
Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates.
Drug Metab Pharmacokinet
; 32(1): 61-68, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28139373
5.
Application of a Human Intestinal Epithelial Cell Monolayer to the Prediction of Oral Drug Absorption in Humans as a Superior Alternative to the Caco-2 Cell Monolayer.
J Pharm Sci
; 105(2): 915-924, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26869436
6.
Utility of cryopreserved hepatocytes suspended in serum to predict hepatic clearance in dogs and monkeys.
Drug Metab Pharmacokinet
; 29(2): 168-76, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24042473
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