Detalles de la búsqueda
1.
1,2-Diphenoxiethane salts as potent antiplasmodial agents.
Bioorg Med Chem Lett
; 28(14): 2485-2489, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29880399
2.
Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells.
J Enzyme Inhib Med Chem
; 33(1): 727-742, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29620429
3.
New non-symmetrical choline kinase inhibitors.
Bioorg Med Chem
; 21(22): 7146-54, 2013 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24080101
4.
New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action.
Eur J Med Chem
; 246: 115003, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36493617
5.
Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors.
Pharmaceutics
; 14(4)2022 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35456549
6.
1 H and 13 C NMR spectral assignments of 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and -bisquinolinium bromide derivatives.
Magn Reson Chem
; 54(11): 905-911, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27402422
7.
New Compounds with Bioisosteric Replacement of Classic Choline Kinase Inhibitors Show Potent Antiplasmodial Activity.
Pharmaceutics
; 13(11)2021 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34834257
8.
Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors.
Pharmaceutics
; 13(9)2021 Aug 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-34575436
9.
Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs).
Eur J Med Chem
; 185: 111842, 2020 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31727470
10.
Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism.
Eur J Med Chem
; 207: 112797, 2020 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32977218
11.
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.
J Med Chem
; 62(3): 1274-1290, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30633509
12.
EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
Biochem Pharmacol
; 155: 213-223, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30006194
13.
Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer.
Cancers (Basel)
; 10(10)2018 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-30360374
14.
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.
Eur J Med Chem
; 143: 683-698, 2018 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29220790
15.
Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors.
Future Med Chem
; 10(15): 1769-1786, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30043647
16.
Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents.
Eur J Med Chem
; 134: 258-270, 2017 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28419928
17.
Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.
Sci Rep
; 7: 46356, 2017 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28406191
18.
Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3',4',5'-Trimethoxyphenyl)-2-Aryl-1H-Imidazole.
Sci Rep
; 6: 26602, 2016 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-27216165
19.
Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).
Sci Rep
; 6: 23793, 2016 Mar 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-27029499
20.
New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1.
Future Med Chem
; 7(4): 417-36, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25875870