Detalles de la búsqueda
1.
Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses.
Antimicrob Agents Chemother
; 65(11): e0098821, 2021 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34424050
2.
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19.
Antimicrob Agents Chemother
; 65(4)2021 03 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33558299
3.
Facile synthesis of the NNRTI microbicide MC-1220 and synthesis of its phosphoramidate prodrugs.
Org Biomol Chem
; 14(3): 940-6, 2016 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-26608715
4.
Synthesis and Anti-HIV-1 Evaluation of Some Novel MC-1220 Analogs as Non-Nucleoside Reverse Transcriptase Inhibitors.
Arch Pharm (Weinheim)
; 349(5): 363-72, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26996241
5.
Isolation and anticancer, anthelminthic, and antiviral (HIV) activity of acylphloroglucinols, and regioselective synthesis of empetrifranzinans from Hypericum roeperianum.
Bioorg Med Chem
; 23(19): 6327-34, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26358281
6.
Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5.
Bioorg Med Chem
; 23(21): 7024-34, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26443549
7.
Antimicrobial and anti-biofilm activity of thiourea derivatives incorporating a 2-aminothiazole scaffold.
Chem Pharm Bull (Tokyo)
; 63(3): 225-36, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25757494
8.
Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits.
Mol Pharm
; 11(12): 4405-14, 2014 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25327902
9.
Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
Bioorg Med Chem
; 22(17): 4893-909, 2014 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25082514
10.
Different molecular mechanisms of inhibition of bovine viral diarrhea virus and hepatitis C virus RNA-dependent RNA polymerases by a novel benzimidazole.
Biochemistry
; 52(21): 3752-64, 2013 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23627712
11.
Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220.
J Antimicrob Chemother
; 68(2): 394-403, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23109186
12.
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents.
Bioorg Med Chem
; 21(21): 6328-36, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24063907
13.
Synthesis and biological evaluation of N-substituted polycyclic imides derivatives.
Acta Pol Pharm
; 70(5): 809-22, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24147359
14.
Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients.
Lipids Health Dis
; 11: 39, 2012 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22414021
15.
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Nat Commun
; 13(1): 621, 2022 02 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35110538
16.
Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors.
Bioorg Med Chem
; 19(23): 7070-84, 2011 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22047799
17.
Accumulation and aberrant composition of cholesteryl esters in Scrapie-infected N2a cells and C57BL/6 mouse brains.
Lipids Health Dis
; 10: 132, 2011 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-21816038
18.
Synthesis and anti-HIV-1 activity of new fluoro-HEPT analogues: an investigation on fluoro versus hydroxy substituents.
Arch Pharm (Weinheim)
; 344(6): 366-71, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21456073
19.
Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives.
Bioorg Med Chem
; 18(8): 2937-53, 2010 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20359898
20.
Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of disease.
BMC Med
; 7: 66, 2009 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-19883495