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1.
Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.
J Med Chem
; 49(5): 1562-75, 2006 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-16509574
2.
Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase.
J Med Chem
; 54(7): 2255-65, 2011 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21375264
3.
Pharmacokinetics and safety of sunitinib malate in subjects with impaired renal function.
J Clin Pharmacol
; 50(4): 472-81, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19779038
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