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1.
Part II: piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation.
Bioorg Med Chem Lett
; 20(4): 1388-94, 2010 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20097563
2.
Thienopyrimidine-based P2Y12 platelet aggregation inhibitors.
Bioorg Med Chem Lett
; 19(20): 5919-23, 2009 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19748783
3.
Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation.
Bioorg Med Chem Lett
; 19(16): 4657-63, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19604694
4.
Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.
Bioorg Med Chem Lett
; 19(21): 6148-56, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19796941
5.
Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors.
J Med Chem
; 46(19): 4043-9, 2003 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-12954057
6.
Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
J Med Chem
; 46(19): 4050-62, 2003 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-12954058
7.
Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time.
Thromb Res
; 112(3): 167-74, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-14967414
8.
Piperazinyl glutamate pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation.
J Med Chem
; 53(5): 2010-37, 2010 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20141147
9.
Pharmacological intervention at disparate sites in the coagulation cascade: comparison of anti-thrombotic efficacy vs bleeding propensity in a rat model of acute arterial thrombosis.
J Thromb Thrombolysis
; 14(2): 113-21, 2002 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12714830
10.
Pharmacological interruption of acute thrombus formation with minimal hemorrhagic complications by a small molecule tissue factor/factor VIIa inhibitor: comparison to factor Xa and thrombin inhibition in a nonhuman primate thrombosis model.
J Pharmacol Exp Ther
; 306(3): 1115-21, 2003 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-12829728
11.
Polymer-assisted solution-phase (PASP) parallel synthesis of an alpha-ketothiazole library as tissue factor VIIa inhibitors.
Bioorg Med Chem Lett
; 13(14): 2363-7, 2003 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-12824035
12.
Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
Bioorg Med Chem Lett
; 13(14): 2319-25, 2003 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-12824026
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