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1.
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.
Proc Natl Acad Sci U S A
; 112(11): 3493-8, 2015 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-25733882
2.
Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration.
Xenobiotica
; 47(12): 1064-1076, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27866461
3.
Mechanistic understanding of translational pharmacokinetic-pharmacodynamic relationships in nonclinical tumor models: a case study of orally available novel inhibitors of anaplastic lymphoma kinase.
Drug Metab Dispos
; 43(1): 54-62, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25349124
4.
Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of anaplastic lymphoma kinase and c-Ros oncogene 1.
J Pharmacol Exp Ther
; 351(1): 67-76, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25073473
5.
Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin.
Drug Metab Dispos
; 41(5): 966-74, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23393219
6.
Expression and functional analysis of hepatic cytochromes P450, nuclear receptors, and membrane transporters in 10- and 25-week-old db/db mice.
Drug Metab Dispos
; 38(12): 2252-8, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-20736321
7.
Metabolism, Excretion, and Pharmacokinetics of Lorlatinib (PF-06463922) and Evaluation of the Impact of Radiolabel Position and Other Factors on Comparability of Data Across 2 ADME Studies.
J Clin Pharmacol
; 60(9): 1254-1267, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32441835
8.
A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies.
Blood Adv
; 1(15): 1088-1100, 2017 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-29296751
9.
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Cancer Cell
; 28(1): 70-81, 2015 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26144315
10.
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
J Med Chem
; 57(11): 4720-44, 2014 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24819116
11.
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
J Med Chem
; 57(4): 1170-87, 2014 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24432909
12.
Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction.
Toxicol Sci
; 135(2): 451-64, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23872713
13.
Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier.
Mol Cancer Ther
; 11(1): 57-65, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22084163
14.
In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay.
Drug Metab Dispos
; 34(8): 1336-44, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16698890
15.
Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.
J Pharmacol Exp Ther
; 319(2): 864-70, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-16905688
16.
Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.
Drug Metab Dispos
; 32(11): 1311-6, 2004 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-15483198
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