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1.
Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.
Bioorg Med Chem Lett
; 21(9): 2711-4, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21183344
2.
3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.
Bioorg Med Chem Lett
; 20(15): 4390-4, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20598884
3.
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptorâ 5 (mGlu5): from an artificial neural network virtual screen to an in vivo tool compound.
ChemMedChem
; 7(3): 406-14, 2012 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-22267125
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