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1.
Dose- and Time-dependency of the Toxicity and Pharmacokinetic Profiles of Bedaquiline and Its N-desmethyl Metabolite in Dogs.
Toxicol Pathol
; 45(5): 663-675, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28789609
2.
Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics.
J Appl Toxicol
; 34(9): 974-92, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24105799
3.
Evaluation of miR-122 and other biomarkers in distinct acute liver injury in rats.
Toxicol Pathol
; 41(5): 795-804, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23143187
4.
Phospholipidosis in rats treated with amiodarone: serum biochemistry and whole genome micro-array analysis supporting the lipid traffic jam hypothesis and the subsequent rise of the biomarker BMP.
Toxicol Pathol
; 40(3): 491-503, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22291062
5.
Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats.
Toxicol Pathol
; 40(7): 1049-62, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22581811
6.
Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients.
PLoS Negl Trop Dis
; 13(1): e0007026, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30650076
7.
Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells.
Toxicol In Vitro
; 22(7): 1789-96, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18672049
8.
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
J Med Chem
; 48(6): 1901-9, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771434
9.
Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling.
Environ Mol Mutagen
; 46(1): 30-42, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15880423
10.
The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation.
Clin Cancer Res
; 21(10): 2297-2304, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25745036
11.
A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development.
Regul Toxicol Pharmacol
; 50(3): 345-52, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18295384
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