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1.
Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
Biochem J
; 473(5): 581-92, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26635351
2.
Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.
Biochem J
; 441(3): 881-7, 2012 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22044397
3.
Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
J Biol Chem
; 286(48): 41510-41519, 2011 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-21953464
4.
Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.
Protein Expr Purif
; 73(2): 189-97, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20451617
5.
High-throughput screening by mass spectrometry: comparison with the scintillation proximity assay with a focused-file screen of AKT1/PKB alpha.
J Biomol Screen
; 12(4): 473-80, 2007 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17478485
6.
High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase.
J Biomol Screen
; 12(5): 628-34, 2007 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-17478478
7.
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.
Nat Med
; 23(9): 1086-1094, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28825717
8.
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Structure
; 22(8): 1161-1172, 2014 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25066137
9.
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
J Med Chem
; 55(3): 1318-33, 2012 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-22196621
10.
A high-throughput competitive scintillation proximity aminoacyl-tRNA synthetase charging assay to measure amino acid concentration.
Anal Biochem
; 363(2): 246-54, 2007 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17316538
11.
A High-throughput two-phase partition assay to measure the activity of lipid-metabolizing enzymes.
Anal Biochem
; 358(2): 266-72, 2006 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16962554
12.
Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants.
Bioorg Med Chem Lett
; 13(22): 4059-63, 2003 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-14592508
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