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1.
Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity.
Bioorg Med Chem
; 103: 117577, 2024 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38518735
2.
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Bioorg Med Chem Lett
; 80: 129084, 2023 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36423823
3.
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
Nature
; 513(7516): 124-7, 2014 Sep 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-25043059
4.
Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.
Bioorg Med Chem
; 25(17): 4876-4886, 2017 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28760529
5.
Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
J Med Chem
; 65(4): 3343-3358, 2022 02 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35166541
6.
Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).
Eur J Med Chem
; 240: 114612, 2022 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35863274
7.
Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.
J Med Chem
; 64(2): 1103-1115, 2021 01 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33404239
8.
Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]Pyridin-2-one-Based p38 MAP Kinase Inhibitors: Partâ 2.
ChemMedChem
; 14(24): 2093-2101, 2019 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31697454
9.
Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach.
J Med Chem
; 60(10): 4358-4368, 2017 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28471657
10.
Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
J Mol Biol
; 428(13): 2769-79, 2016 07 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27220631
11.
Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases.
J Med Chem
; 59(3): 1149-64, 2016 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26789933
12.
Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate.
Nat Struct Mol Biol
; 22(7): 581-5, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-26098317
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