Detalles de la búsqueda
1.
A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation.
J Pharmacol Exp Ther
; 386(1): 80-92, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37142443
2.
Thymic lymphoma detection in RORγ knockout mice using 5-hydroxymethylcytosine profiling of circulating cell-free DNA.
Toxicol Appl Pharmacol
; 473: 116582, 2023 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37295732
3.
Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster Models.
Toxicol Pathol
; 50(3): 280-293, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35128980
4.
3'Pool-seq: an optimized cost-efficient and scalable method of whole-transcriptome gene expression profiling.
BMC Genomics
; 21(1): 64, 2020 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31959126
5.
Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury.
J Neuroinflammation
; 15(1): 142, 2018 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29759062
6.
Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder.
Neurobiol Dis
; 77: 220-7, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25796564
7.
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Proc Natl Acad Sci U S A
; 109(8): 3125-30, 2012 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22315408
8.
Comparing molecular and computational approaches for detecting viral integration of AAV gene therapy constructs.
Mol Ther Methods Clin Dev
; 29: 395-405, 2023 Jun 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37251978
9.
Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.
Biomarkers
; 17(6): 524-31, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22672085
10.
Biodistribution and Tolerability of AAV-PHP.B-CBh-SMN1 in Wistar Han Rats and Cynomolgus Macaques Reveal Different Toxicologic Profiles.
Hum Gene Ther
; 33(3-4): 175-187, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34931542
11.
Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease.
J Pharmacol Exp Ther
; 336(1): 64-76, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20923867
12.
Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 21(9): 2631-6, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21269825
13.
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014.
Bioorg Med Chem Lett
; 21(9): 2637-40, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21269827
14.
Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling.
Transl Psychiatry
; 11(1): 136, 2021 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33608496
15.
An in vitro alveolar epithelial cell model recapitulates LRRK2 inhibitor-induced increases in lamellar body size observed in preclinical models.
Toxicol In Vitro
; 70: 105012, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33049313
16.
Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.
J Pharmacol Exp Ther
; 334(1): 269-77, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20363853
17.
GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons.
PLoS One
; 15(6): e0233895, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32497062
18.
An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson's Disease and G2019S LRRK2 Cohorts.
J Parkinsons Dis
; 10(2): 623-629, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32007961
19.
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia.
Nat Neurosci
; 23(11): 1352-1364, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33097921
20.
Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder.
Transl Psychiatry
; 9(1): 151, 2019 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31123247