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1.
Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial.
Respir Res
; 24(1): 133, 2023 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37198686
2.
Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections.
Antimicrob Agents Chemother
; 65(7): e0031621, 2021 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33941518
3.
Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts.
Prostaglandins Other Lipid Mediat
; 152: 106486, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33011365
4.
Small-molecule WNK inhibition regulates cardiovascular and renal function.
Nat Chem Biol
; 12(11): 896-898, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27595330
5.
Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats.
Pulm Pharmacol Ther
; 49: 95-103, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29408757
6.
Correction for Plaunt et al., "Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections".
Antimicrob Agents Chemother
; 66(11): e0125622, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36222535
7.
Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects.
J Transl Med
; 12: 340, 2014 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25491597
8.
Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice.
Front Immunol
; 14: 1185727, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37441081
9.
The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species.
Front Pharmacol
; 14: 1208780, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37538173
10.
An optimized method of extracting and quantifying active Neutrophil serine proteases from human whole blood cells.
PLoS One
; 17(8): e0272575, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36044421
11.
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Anal Biochem
; 394(1): 56-61, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19622340
12.
Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.
J Med Chem
; 60(20): 8466-8481, 2017 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29035537
13.
Discovery and Characterization of Allosteric WNK Kinase Inhibitors.
ACS Chem Biol
; 11(12): 3338-3346, 2016 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27712055
14.
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
J Med Chem
; 58(11): 4749-70, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25953419
15.
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
J Med Chem
; 58(23): 9382-94, 2015 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26540564
16.
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
ACS Med Chem Lett
; 4(12): 1203-7, 2013 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900631
17.
Optimization of halopemide for phospholipase D2 inhibition.
Bioorg Med Chem Lett
; 17(8): 2310-1, 2007 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17317170
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