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1.
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Nat Rev Neurosci
; 22(2): 111-131, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33432241
2.
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
Nat Chem Biol
; 20(5): 646-655, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38347213
3.
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
EMBO J
; 39(17): e104671, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32757223
4.
Effective Inhibition of TDP-43 Aggregation by Native State Stabilization.
Angew Chem Int Ed Engl
; 63(3): e202314587, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37949836
5.
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.
Proc Natl Acad Sci U S A
; 117(9): 4971-4982, 2020 03 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32075919
6.
Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM.
Proc Natl Acad Sci U S A
; 117(12): 6866-6874, 2020 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32161130
7.
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies.
Chem Soc Rev
; 51(2): 513-565, 2022 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34889934
8.
Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils.
J Am Chem Soc
; 144(24): 10723-10735, 2022 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-35679155
9.
N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease.
Neurobiol Dis
; 174: 105884, 2022 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-36220612
10.
On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid.
Anal Chem
; 94(29): 10415-10426, 2022 07 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35786947
11.
Pathological substrate of memory impairment in multiple system atrophy.
Neuropathol Appl Neurobiol
; 48(7): e12844, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35906771
12.
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.
Mol Ther
; 29(5): 1862-1882, 2021 05 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33545358
13.
α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.
Proc Natl Acad Sci U S A
; 116(5): 1511-1519, 2019 01 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-30651314
14.
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau.
J Biol Chem
; 295(23): 7905-7922, 2020 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32341125
15.
A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation.
J Am Chem Soc
; 143(26): 9798-9812, 2021 07 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34161085
16.
Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model: This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". The articles are accompanied by a Preface "How good are cellular models?".
J Neurochem
; 157(4): 891-898, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33336386
17.
Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get.
J Neurochem
; 157(4): 872-888, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32772367
18.
Lewy body-associated proteins: victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein.
Neurobiol Dis
; 156: 105417, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34102275
19.
To target Tau pathologies, we must embrace and reconstruct their complexities.
Neurobiol Dis
; 161: 105536, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34718129
20.
Site-Specific Phosphorylation of Huntingtin Exonâ 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases.
Chembiochem
; 22(1): 217-231, 2021 01 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32805086