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1.
Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.
J Am Chem Soc
; 140(36): 11424-11437, 2018 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30107725
2.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30249687
3.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29941635
4.
Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin.
Molecules
; 22(4)2017 Mar 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-28358310
5.
In Vitro and In Vivo Pharmacokinetics of Aminoalkylated Diarylpropanes NP085 and NP102.
Antimicrob Agents Chemother
; 60(5): 3065-9, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26953201
6.
Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model.
Malar J
; 14: 8, 2015 Jan 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-25563929
7.
Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.
Bioorg Med Chem
; 23(22): 7240-50, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26522089
8.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30355750
9.
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model.
J Med Chem
; 65(24): 16695-16715, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36507890
10.
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and In Vivo Oral Efficacy Studies.
J Med Chem
; 64(8): 5198-5215, 2021 04 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33844521
11.
New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase.
ACS Infect Dis
; 7(1): 34-46, 2021 01 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33319990
12.
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
J Med Chem
; 64(13): 9444-9457, 2021 07 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34138573
13.
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
J Med Chem
; 64(1): 719-740, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33395287
14.
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
J Med Chem
; 64(17): 12790-12807, 2021 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34414766
15.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33573376
16.
Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment.
ACS Omega
; 5(12): 6967-6982, 2020 Mar 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-32258933
17.
Synthesis, Structure-Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity.
ACS Infect Dis
; 6(7): 1951-1964, 2020 07 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32470286
18.
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
J Med Chem
; 63(21): 13013-13030, 2020 11 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33103428
19.
Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.
ACS Infect Dis
; 5(2): 303-315, 2019 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30525439
20.
Antiplasmodial imidazopyridazines: structure-activity relationship studies lead to the identification of analogues with improved solubility and hERG profiles.
Medchemcomm
; 9(10): 1733-1745, 2018 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30429978