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1.
A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.
Bioorg Med Chem Lett
; 47: 128113, 2021 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33991628
2.
An αv-RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities.
Angew Chem Int Ed Engl
; 57(13): 3298-3321, 2018 03 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-28944552
3.
Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.
Bioorg Med Chem Lett
; 22(6): 2266-70, 2012 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22342143
4.
Translational pharmacology of an inhaled small molecule αvß6 integrin inhibitor for idiopathic pulmonary fibrosis.
Nat Commun
; 11(1): 4659, 2020 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32938936
5.
Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.
J Med Chem
; 62(19): 8796-8808, 2019 10 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31497959
6.
Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvß6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.
J Med Chem
; 62(16): 7543-7556, 2019 08 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31381331
7.
Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvß6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 61(18): 8417-8443, 2018 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30215258
8.
From PIM1 to PI3Kδ via GSK3ß: Target Hopping through the Kinome.
ACS Med Chem Lett
; 8(10): 1093-1098, 2017 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29057057
9.
Bringing kinases into focus: efficient drug design through the use of chemogenomic toolkits.
Curr Med Chem
; 13(15): 1735-48, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16787217
10.
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
J Med Chem
; 58(18): 7381-99, 2015 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26301626
11.
Evaluation of rat intestinal absorption data and correlation with human intestinal absorption.
Eur J Med Chem
; 38(3): 233-43, 2003 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-12667690
12.
On the mechanism of human intestinal absorption.
Eur J Med Chem
; 37(7): 595-605, 2002 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12126778
13.
Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents.
ACS Med Chem Lett
; 5(11): 1207-12, 2014 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25408832
14.
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.
J Med Chem
; 55(15): 6700-15, 2012 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-22746295
15.
Rate-limited steps of human oral absorption and QSAR studies.
Pharm Res
; 19(10): 1446-57, 2002 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12425461
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