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1.
Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry.
J Chem Inf Model
; 59(5): 2046-2062, 2019 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30817167
2.
A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.
J Biol Chem
; 291(24): 12724-12731, 2016 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27129215
3.
The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.
Bioorg Med Chem Lett
; 26(19): 4781-4784, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27595421
4.
Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids.
Tetrahedron
; 71(37): 6424-6436, 2015 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-26257440
5.
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J Med Chem
; 65(21): 14326-14336, 2022 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36314537
6.
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
ACS Med Chem Lett
; 12(5): 782-790, 2021 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34055226
7.
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
Bioorg Med Chem Lett
; 20(23): 7137-41, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20947352
8.
1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.
Bioorg Med Chem Lett
; 20(23): 7142-6, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20932750
9.
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Bioorg Med Chem Lett
; 19(19): 5803-6, 2009 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19713111
10.
Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.
Bioorg Med Chem Lett
; 19(1): 40-6, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19038548
11.
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
J Med Chem
; 60(8): 3511-3517, 2017 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28300404
12.
Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform.
J Biomol Screen
; 21(2): 127-35, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26442913
13.
Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.
Eur J Pharmacol
; 663(1-3): 40-50, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21575625
14.
Enantioselective total synthesis of quadrigemine C and psycholeine.
J Am Chem Soc
; 124(31): 9008-9, 2002 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-12148978
15.
Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the alpha 2 delta-1 subunit of voltage gated calcium channel.
Bioorg Med Chem Lett
; 14(10): 2463-7, 2004 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15109633
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