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1.
A Food Effect Study of an Oral Thrombin Inhibitor and Prodrug Approach To Mitigate It.
Mol Pharm
; 13(4): 1197-205, 2016 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26886576
2.
Pharmacokinetics, pharmacodynamics and food effect of LB30870, a novel direct thrombin inhibitor, after single oral doses in healthy men.
Xenobiotica
; 45(8): 663-71, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25673087
3.
Absorption, metabolism and excretion of [14C]gemigliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.
Xenobiotica
; 44(6): 522-30, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24304170
4.
Absorption, distribution, metabolism and excretion of gemigliptin, a novel dipeptidyl peptidase IV inhibitor, in rats.
Xenobiotica
; 44(7): 627-34, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24738939
5.
Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug.
Bioorg Med Chem Lett
; 23(17): 4779-84, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23899618
6.
Pharmacokinetics of LB80331 and LB80317 following oral administration of LB80380, a new antiviral agent for chronic hepatitis B (CHB), in healthy adult subjects, CHB patients, and mice.
Antimicrob Agents Chemother
; 53(5): 1779-85, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19223649
7.
Pharmacokinetics and pharmacodynamics of LC15-0444, a novel dipeptidyl peptidase IV inhibitor, after multiple dosing in healthy volunteers.
Br J Clin Pharmacol
; 68(6): 883-90, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-20002082
8.
Pharmacokinetic Interactions Between Gemigliptin and Metformin, and Potential Differences in the Pharmacokinetic Profile of Gemigliptin Between the Mexican and Korean Populations: A Randomized, Open-label Study in Healthy Mexican Volunteers.
Clin Ther
; 40(10): 1729-1740, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30249366
9.
Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan.
J Pharm Pharm Sci
; 10(4): 519-36, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-18261372
10.
Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: evidence for multifactorial multidrug resistance.
Eur J Pharm Sci
; 29(2): 102-10, 2006 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16844360
11.
Tolerability and pharmacokinetics of two formulations of megestrol acetate under fed conditions in healthy volunteers.
Clin Ther
; 37(2): 439-47, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25450470
12.
Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2).
BMC Med
; 2: 16, 2004 May 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-15125776
13.
Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: first new anti-diabetic drug in the history of Korean pharmaceutical industry.
Arch Pharm Res
; 36(10): 1185-8, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23771499
14.
Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor.
Drug Metab Pharmacokinet
; 27(2): 216-22, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22240842
15.
Practical aspects of transporter model systems: a case study involving SQV.
Drug Metab Rev
; 36(2): 377-89, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15237860
16.
Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.
Biochem Biophys Res Commun
; 310(1): 222-7, 2003 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-14511674
17.
Differentiation of gut and hepatic first-pass loss of verapamil in intestinal and vascular access-ported (IVAP) rabbits.
Drug Metab Dispos
; 32(11): 1293-8, 2004 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-15304428
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